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Cell Immortalization

  • Book
  • © 2000

Overview

Editors:
  1. Alvaro Macieira-Coelho

    1. INSERM, Versailles, France

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  • This is the first book which comprehensively deals with cell immortalization and its relationship with cancer, aging, homeostasis, and the development of organs and organisms

Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 24)

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-VII
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  2. A Theory on Cellular Aging and Cell Immortalization

    • J. W. I. M. Simons
    Pages 1-21

  3. Cell Immortality: Maintenance of Cell Division Potential

    • C. Bernstein, H. Bernstein, C. Payne
    Pages 23-50

  4. Comparative Biology of Cell Immortalization

    • A. Macieira-Coelho
    Pages 51-80

  5. Clonal Life Cycle of Paramecium in the Context of Evolutionally Acquired Mortality

    • Y. Takagi
    Pages 81-101

  6. Cellular Genealogy of In-Vitro Senescence and Immortalization

    • T. Matsumura
    Pages 103-119

  7. SV40-Mediated Immortalization

    • H. L. Ozer
    Pages 121-153

  8. Concepts of Immortalization in Human Mammary Epithelial Cells

    • K. Swisshelm
    Pages 155-172

  9. Telomeres and Cell Division Potential

    • K. Perrem, R. R. Reddel
    Pages 173-189

  10. Cellular Mortality and Immortalization: A Complex Interplay of Multiple Gene Functions

    • R. Wadhwa, S. C. Kaul, Y. Mitsui
    Pages 191-204

  11. Back Matter

    Pages 205-207
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Keywords

About this book

The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera­ tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim­ ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris­ ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera­ tive phenotypes has to be seen using the perspective of comparative biology.

Editors and Affiliations

  • INSERM, Versailles, France

    Alvaro Macieira-Coelho

Bibliographic Information

  • Book Title: Cell Immortalization

  • Editors: Alvaro Macieira-Coelho

  • Series Title: Progress in Molecular and Subcellular Biology

  • DOI: https://doi.org/10.1007/978-3-662-06227-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Hardcover ISBN: 978-3-540-65618-0Published: 17 September 1999

  • Softcover ISBN: 978-3-642-08491-1Published: 04 December 2010

  • eBook ISBN: 978-3-662-06227-2Published: 17 April 2013

  • Series ISSN: 0079-6484

  • Series E-ISSN: 2197-8484

  • Edition Number: 1

  • Number of Pages: VII, 208

  • Topics: Cell Biology, Cancer Research, Biochemistry, general, Oncology

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