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The past few years have seen rapid progress in apoptosis research. This volume deals with many of the recent advances made in uncovering the molecular and cellular basis of apoptosis and elaborates on how this accumulating knowledge is helping us to understand the significance of apoptosis in pathogenesis of diseases arising from inappropriate cell death. Further, mechanistic aspects of cell death and role of apoptosis in disease is covered. The articles published in this volume are written by leading experts in the field and should be a vital resource for researchers in biomedicine and cancer research.
Caspases in Cell Death.- Proteolytic Targets in Cell Death.- The Point of No Return: Mitochondria, Caspases, and the Commitment to Cell Death.- Serpins and Regulation of Cell Death.- The IAP Family of Apoptotic Regulators.- Apoptosis Versus Necrosis: The Shape of Neuronal Cell Death.- Prevention of Neuronal Cell Death by Bcl-2.- CD95 (APO-1/Fas) in Hematopoietic Diseases.- The Cornified Envelope: A Model of Cell Death in the Skin.- Radiation-Induced Cell Death and its Implications in Human Disease.- T Cell Apoptosis in HIV Infection: Mechanism and Relevance for AIDS Pathogenesis.