Editors:
- First book to give a full overview on genome integrity in different species
- Spans from microorganisms to humans
- Addresses the connection between genome integrity and human disease
- Written by an international panel of experts
Part of the book series: Genome Dynamics and Stability (GENOME, volume 1)
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (17 chapters)
-
Front Matter
-
Replicative Double-Strand Break Repair
-
Front Matter
-
-
Facets of Double-Strand Break Repair
-
Front Matter
-
-
DNA Repair and Pleiotropic Interactions
-
Front Matter
-
-
Radiation and other Genotoxic Stress
-
Front Matter
-
About this book
Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.
Bibliographic Information
Book Title: Genome Integrity
Book Subtitle: Facets and Perspectives
Editors: Dirk-Henner Lankenau
Series Title: Genome Dynamics and Stability
DOI: https://doi.org/10.1007/b104871
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2007
Hardcover ISBN: 978-3-540-37528-9Published: 07 November 2006
Softcover ISBN: 978-3-642-07226-0Published: 25 November 2010
eBook ISBN: 978-3-540-37531-9Published: 14 October 2006
Series ISSN: 1861-3373
Series E-ISSN: 1861-3381
Edition Number: 1
Number of Pages: XI, 496
Topics: Cell Biology, Biochemistry, general, Human Genetics