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  • © 2013

Studies on Alzheimer's Disease

  • Reviews the basic science and clinical knowledge of the role of oxidative stress in the pathology of Alzheimer’s disease
  • Describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment of Alzheimer's disease
  • Provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents
  • Includes supplementary material: sn.pub/extras

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
  2. Mechanisms

    1. Front Matter

      Pages 71-71
    2. Metal Dysfunction in Alzheimer’s Disease

      • Rosanna Squitti, Mariacristina Siotto, Carlo Salustri, Renato Polimanti
      Pages 73-97
    3. Brain Oxidative Stress in the Pathogenesis and Progression of Alzheimer’s Disease

      • Rukhsana Sultana, Aaron M. Swomley, D. Allan Butterfield
      Pages 99-118
    4. Brain Hypometabolism, Oxidative Stress, Maternal Transmission, and Risk of Late-Onset Alzheimer’s Disease

      • Lisa Mosconi, John Murray, Pauline McHugh, Mony de Leon
      Pages 137-157
    5. Stress and HPA Axis Dysfunction in Alzheimer’s Disease

      • Yash B. Joshi, Domenico Praticò
      Pages 159-165
  3. Clinics

    1. Front Matter

      Pages 167-167
    2. Peripheral Biomarkers of Oxidative Stress in Alzheimer’s Disease

      • Fabio Di Domenico, Marzia Perluigi
      Pages 185-199
    3. Nutrition, Lifestyle and Oxidative Stress: Prevention of Alzheimer’s Disease

      • M. Cristina Polidori, Ludger Pientka
      Pages 201-209
    4. Are Antioxidant Food and Nutrients Useful in Preventing Cognitive Decline?

      • Luc Letenneur, Catherine Feart, Pascale Barberger-Gateau
      Pages 211-222
    5. Antioxidant Clinical Trials in Mild Cognitive Impairment and Alzheimer’s Disease

      • Patrizia Mecocci, M. Cristina Polidori, Domenico Praticó
      Pages 223-232

About this book

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress,” in the pathology of Alzheimer’s disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer’s Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimer’s Disease.

Editors and Affiliations

  • Pharmacology, Temple University, Philadelphia, USA

    Domenico Praticὸ

  • Istituto di Gerontologia e Geriatria, Università degli Studi di Perugia, Perugia, Italy

    Patrizia Mecocci

About the editors

Dr. Domenico Praticò received his M.D. from the University of Rome “La Sapienza,” School of Medicine where he completed a residency program in Internal Medicine. After receiving a European Research Award fellowship, he spent two years of post-doctoral training at the University of Dublin as a fellow in the Center for Cardiovascular Science. Next, he joined the University of Pennsylvania as Research Associate, where later he was promoted to Assistant Professor. He is currently Professor of Pharmacology, Microbiology and Immunology and member of the Center for Translational Medicine at Temple University. His main research interest is oxidative biology with a particular focus on bioactive lipids, their metabolic pathways, and their role as biological mediators of cellular and molecular events in the pathogenesis of human diseases, including neurodegenerative and cardiovascular diseases. Dr. Pratico has published more than 195 papers in peer-reviewed scientific journals, and has received many awards for his research accomplishments including the Irvine H. Page Award, Neurosciences Education and Research Award, The Zenith Award from the Alzheimer’s Association, and the Dorothy Dillon Eweson Lectureship.

Dr. Patrizia Mecocci received her MD from the University of Perugia, School of Medicine where she completed a residency program in Geriatrics. She also earned a PhD in Biology and Physiopathology of Aging at the University of Modena (Italy). After receiving a grant from the Italian National Research Council (CNR),  she spent three years as research fellow first  at the Department of Psychiatry and Neurochemistry at the University of Lund (Sweden) and then at the Department of Neurology, MGH-Harvard Medical School in Boston. She then started the academic career at the University of Perugia where she is now Full Professor in Gerontology and Geriatrics and Director of the Geriatric Clinic.  Dr. Mecocci’s research is mainly devoted to clinicalgeriatrics, with a specific interest on brain aging and dementia and on age-related biological modifications,  with a particular focus on the role of oxidants and antioxidants in neurodegenerative and cardiovascular diseases.  She has been PI or co-investigator in research projects funded by the European Commission and by the Italian Ministry of Research. She is author of more than 180 papers in peer-reviewed scientific journals and 30 books and book chapters.

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access