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Male Germline Stem Cells: Developmental and Regenerative Potential

  • Book
  • © 2011

Overview

Editors:
  1. Kyle E. Orwig

    1. Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Brian P. Hermann

    1. Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Rapid expansion of the male germ cell field is fuelled by implications for understanding pluripotent and adult tissue stem cell biology
  • Chapters are authored by the leading authorities and pioneers in the fields of germ cell biology and stem cell biology
  • Progress understanding and manipulating male germ cells has implications for regenerative medicine
  • Includes supplementary material: sn.pub/extras

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Germline Developmental Potential

    1. Front Matter

      Pages 1-1
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    2. Pathways to Pluripotency: How Germ Cells Make Stem Cells

      • Peter J. Donovan
      Pages 3-24

    3. Pluripotent Stem Cells from the Postnatal Testis: Unlocking the Potential of Spermatogonial Stem Cells

      • Marco Seandel, Ilaria Falciatori, Shahin Rafii
      Pages 25-47

    4. Making Germ Cells from Human Embryonic Stem Cells

      • Sonya M. Schuh-Huerta, Renee A. Reijo Pera
      Pages 49-86

  4. Translation and Regenerative Potential of Spermatogonial Stem Cells

    1. Front Matter

      Pages 177-177
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    2. Regenerative Potential of Spermatogenesis after Gonadotoxic Therapies

      • Gunapala Shetty, Gensheng Wang, Marvin L. Meistrich
      Pages 179-203

    3. Testicular Xenografting

      • Stefan Schlatt, Jose R. Rodriguez-Sosa, Ina Dobrinski
      Pages 205-225

    4. Translating Spermatogonial Stem Cell Transplantation to the Clinic

      • Brian P. Hermann, Kyle E. Orwig
      Pages 227-253

  5. Back Matter

    Pages 255-262
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Keywords

About this book

Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.

Reviews

From the reviews:

“It provides an in-depth review of current research and future clinical perspectives. … written for basic science and clinical researchers interested in stem cell biology, as well as those interested broadly in developmental and reproductive biology. Biomedical scientists and clinicians interested in testicular cancer and fertility/infertility also will appreciate the wealth of information and insight. … This is an outstanding contribution to the literature on mammalian germ cell biology. … will be valued by all those interested in germ cells and stem cell-based therapies.” (Bruce A. Fenderson, Doody’s Review Service, June, 2011)

Editors and Affiliations

  • Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, USA

    Kyle E. Orwig, Brian P. Hermann

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