Studies on Renal Disorders

1. Front Matter

   Pages i-xviii

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2. Oxidative Stress

   1. Front Matter

      Pages 1-1

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   2. Oxidative Stress Injury in Glomerular Mesangium

      • Josef Pfeilschifter, Karl-Friedrich Beck

      Pages 3-23

   3. Transition Metals and Other Forms of Oxidative Protein Damage in Renal Disease

      • Vincent M. Monnier, Ina Nemet, David R. Sell, Miriam F. Weiss

      Pages 25-50

   4. Cyclooxygenase in the Kidney and Oxidative Stress

      • Raymond C. Harris

      Pages 51-69

   5. Renin-Angiotensin System in the Kidney and Oxidative Stress: Local Renin-Angiotensin-Aldosterone System and NADPH Oxidase-Dependent Oxidative Stress in the Kidney

      • Hideyasu Kiyomoto, Hiroyuki Kobori, Akira Nishiyama

      Pages 71-91

   6. Thiamine in Diabetic Renal Disease: Dietary Insufficiency, Renal Washout, Antistress Gene Response, Therapeutic Supplements, Risk Predictor, and Link to Genetic Susceptibility

      • Paul J. Thornalley, Naila Rabbani

      Pages 93-104

   7. Novel Members of the Globin Family and Their Function Against Oxidative Stress

      • Hiroshi Nishi, Masaomi Nangaku

      Pages 105-117

3. Clinical Aspects of Oxidative Stress in the Kidney

   1. Front Matter

      Pages 119-119

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   2. Hypertension

      • Bernardo Rodriguez-Iturbe, Nosratola D. Vaziri

      Pages 121-142

   3. Uric Acid and Oxidative Stress

      • Yuri Y. Sautin, Witcha Imaram, Kyung Mee Kim, Alexander Angerhofer, George Henderson, Richard Johnson

      Pages 143-159

   4. Reactive Oxygen and Nitrogen Species, Oxidative and Nitrosative Stress, and Their Role in the Pathogenesis of Acute Kidney Injury

      • Eisei Noiri, Francesco Addabbo, Michael S. Goligorsky

      Pages 161-177

   5. Oxidative Stress in the Kidney: Proximal Tubule Disorders

      • Sara Terryn, Olivier Devuyst

      Pages 179-203

   6. Iron Metabolism and Oxidative Stress

      • Abolfazl Zarjou, József Balla, György Balla, Anupam Agarwal

      Pages 205-228

   7. Hypoxia, Oxidative Stress, and the Pathophysiology of Contrast-Media-Induced Nephropathy

      • Samuel N. Heyman, Seymour Rosen, Mogher Khamaisi, Jean-Marc Odee, Christian Rosenberger

      Pages 229-256

   8. Cardiovascular Complications in Renal Failure: Implications of Advanced Glycation End Products and Their Receptor RAGE

      • Hidenori Koyama, Yoshiki Nishizawa

      Pages 257-292

   9. Infection and the Kidney

      • Chih-Wei Yang

      Pages 293-304

   10. Oxidative/Carbonyl Stress in the Renal Circulation and Cardiovascular Renal Injury

       • Takefumi Mori, Toshio Miyata, Sadayoshi Ito

       Pages 305-320

4. Current Therapy Targeting Oxidative tress

   1. Front Matter

      Pages 321-321

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5. Current Therapy Targeting Oxidative Stress

   1. The Renin Angiotensin System

      • Josephine M. Forbes, Mark E. Cooper

      Pages 323-335

Conditions such as oxidative stress and hypoxia, which have a generalized impact on the oxygen metabolism, have been implicated in the genesis of kidney disease. This means that deepening our understanding of the pathobiology of oxygen metabolism in such diseases could be a fruitful path towards tangible clinical benefits. Studies in Renal Disorder collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances. The causal role of impaired oxygen metabolism in kidney disease has numerous clinical implications. It affects our understanding of the therapeutic benefits accruing from anti-hypertensive agents; the way we control hyperglycemia/hyperinsulinemia and hyperlipidemia; and our use of dietary approaches to the correction of obesity. The defensive mechanisms against oxidative stress, such as the Nrf2-Keap1 system, and hypoxia, such as the PHD-HIF system, have recently been explored in various cells, including kidney cells. These mechanisms include intracellular sensors for oxidative stress and hypoxia. This means that novel approaches targeting these sensors may offer clinical benefits in kidney disease in which oxidative stress and/or hypoxia is a final, common pathway.

• hypoxia
• kidney disease
• nitrosative stress
• oxidative stress
• oxygen metabolism

From the reviews:

“This book is a collection of reviews on derangements of oxygen metabolism in kidney diseases. … addressed to students (mostly postgraduate), researchers, and academic clinicians … . I liked the organization of each chapter with an abstract, key words, introduction, and conclusion as well as extensive, up-to-date, relevant references. … This is the only book that I am aware of that is an extensive, updated review of abnormal oxygen metabolism in a large number of pathologic renal diseases.” (Mony Fraer, Doody’s Review Service, July, 2011)

• Graduate School of Medicine, Division of Molecular Medicine and Thera, Tohoku University, Sendai, Japan

  Toshio Miyata

• Medizinische Klinik IV, Universitätsklinikum Erlangen, Erlangen, Germany

  Kai-Uwe Eckardt

• Graduate School of Medicine &, Faculty of Medicine, University of Tokyo, Tokyo, Japan

  Masaomi Nangaku

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