Cell Cycle Control

1. Front Matter

   Pages i-xii

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2. Overviews Of Cell Cycle Control In Different Organisms

   1. Front Matter

      Pages 1-153

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   2. Cell Cycle Molecules and Mechanisms of the Budding and Fission Yeasts

      • Tim Humphrey, Amanda Pearce

      Pages 3-29

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   3. The Plant Cell Cycle

      • John H. Doonan

      Pages 31-50

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   4. The C. elegans Cell Cycle

      • Sander van den Heuvel

      Pages 51-67

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   5. Developmental Control of Growth and Cell Cycle Progression in Drosophila

      • Lisa Swan, Jeremy Kupsco, Robert J.

      Pages 69-94

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   6. The Xenopus Cell Cycle

      • Anna Philpott, P. Renee Yew

      Pages 95-112

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   7. The Mammalian Cell Cycle

      • Jane V. Harper, Gavin Brooks

      Pages 113-153

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3. Cell Cycle Study Methods And Techniques

   1. Front Matter

      Pages 155-235

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   2. Synchronization of Cell Populations in G1/S and G2/M Phases of the Cell Cycle

      • Jane V. Harper

      Pages 157-166

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   3. Mapping Origins of DNA Replication in Eukaryotes

      • Susan A. Gerbi

      Pages 167-180

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   4. In Situ Assay for Analyzing the Chromatin Binding of Proteins in Fission Yeast

      • Stephen E. Kearsey, Lydia Brimage, Mandana Namdar, Emma Ralph, Xiaowen Yang

      Pages 181-188

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   5. Application of Magnetic Beads to Purify Cells Transiently Transfected With Plasmids Encoding Short Hairpin RNAs

      • Peter D. Adams

      Pages 189-196

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   6. The Cell Cycle and Virus Infection

      • Stevan R. Emmett, Brian Dove, Laura Mahoney, Torsten Wurm, Julian A. Hiscox

      Pages 197-218

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   7. Methods for Preparation of Proteins and Protein Complexes That Regulate the Eukaryotic Cell Cycle for Structural Studies

      • Julie Welburn, Jane Endicott

      Pages 219-235

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4. Overviews Of Cell Cycle Control In Different Organisms

   1. Front Matter

      Pages 237-391

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   2. E2F Transcription Factors and pRb Pocket Proteins in Cell Cycle Progression

      • Ludger Hauck, Rüdiger von Harsdorf

      Pages 239-245

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   3. Forkhead (FOX) Transcription Factors and the Cell Cycle

      • Katrina A. Bicknell

      Pages 247-262

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   4. Measurement of Geminin Activity in Xenopus Egg Extracts

      • Thomas J. McGarry

      Pages 263-278

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   5. CDK-Activating Kinases

      • Stéphane Larochelle, Robert P. Fisher

      Pages 279-290

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The fundamental question of how cells grow and divide has perplexed biologists since the development of the cell theory in the mid-19th century, when it was recognized by Virchow and others that “all cells come from cells.” In recent years, considerable effort has been applied to the identification of the basic molecules and mechanisms that regulate the cell cycle in a number of different organisms. Such studies have led to the elucidation of the central paradigms that underpin eukaryotic cell cycle control, for which Lee Hartwell, Tim Hunt, and Paul Nurse were jointly awarded the Nobel Prize for Medicine and Physiology in 2001 in recognition of their seminal contributions to this field. The importance of understanding the fundamental mechanisms that modulate cell division has been reiterated by relatively recent discoveries of links between cell cycle control and DNA repair, growth, cellular metabolism, development, and cell death. This new phase of integrated cell cycle research provides further challenges and opportunities to the biological and medical worlds in applying these basic concepts to understanding the etiology of cancer and other proliferative diseases.

• DNA
• Drosophila
• bacteria
• cell
• cell cycle
• development
• protein
• protein complexes
• replication
• transcription

• MRC Radiation and Genome Stability Unit, Harwell, Didcot

  Tim Humphrey

• School of Pharmacy, University of Reading Whiteknights, Reading

  Gavin Brooks

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