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Technical Aspects of Toxicological Immunohistochemistry

System Specific Biomarkers

  • Provides a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues

  • Explores the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification

  • Important reference for immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi
  2. Importance of Fluorescent In Situ Hybridization in Rodent Tumors

    • Ana Mendes-da-Silva, Filomena Adega, Raquel Chaves
    Pages 21-49
  3. Immunohistochemistry and Female Reproductive Toxicology: The Ovary and Mammary Glands

    • Daniel G. Cyr, Patrick J. Devine, Isabelle Plante
    Pages 113-145
  4. Bone Marker and Immunohistochemistry Changes in Toxic Environments

    • Ahmad Nazrun Shuid, Isa Naina Mohamed, Norliza Muhammad, Elvy Suhana Mohd Ramli, Norazlina Mohamed
    Pages 193-213
  5. Biomarkers of Skeletal Muscle Injury in the Rat

    • Nivaldo A. Parizotto, Natalia C. Rodrigues, Paulo Sergio Bossini, Michael R. Hamblin
    Pages 215-226
  6. Back Matter

    Pages 227-231

About this book

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

Editors and Affiliations

  • Health Products and Food Branch Health Canada, Regulatory Toxicology Research Division Food Directorate, Ottawa, Canada

    Syed A. Aziz, Rekha Mehta

About the editors

Syed A Aziz, Ph.D.

Regulatory Toxicology Research Division, Bureau of Chemical Safety

Food Directorate, Health Products and Food Branch

Health Canada

Adjunct professor, Faculty of Medicine Dept. of Pathology

University of Ottawa

Rekha Mehta, Ph.D.

Regulatory Toxicology Research Division, Bureau of Chemical Safety

Food Directorate, Health Products and Food Branch

Health Canada.

Bibliographic Information

  • Book Title: Technical Aspects of Toxicological Immunohistochemistry

  • Book Subtitle: System Specific Biomarkers

  • Editors: Syed A. Aziz, Rekha Mehta

  • DOI: https://doi.org/10.1007/978-1-4939-1516-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-1515-6Published: 24 December 2015

  • Softcover ISBN: 978-1-4939-7965-3Published: 27 March 2019

  • eBook ISBN: 978-1-4939-1516-3Published: 23 December 2015

  • Edition Number: 1

  • Number of Pages: XI, 231

  • Number of Illustrations: 50 b/w illustrations, 3 illustrations in colour

  • Topics: Cell Biology, Pharmacology/Toxicology, Biological Microscopy, Pathology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access