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Examines the basic science and clinical knowledge of the role of oxidative stress in the pathology of numerous pediatric disorders
Describes current diagnostic tools, laboratory methods and technology for treatment and prevention of pediatric disorders
Covers emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents
This volume examines the role of oxidative stress in the pathology of numerous pediatric disorders. It covers a wide range of topics including the chemistry and biology of reactive oxygen species and nitric oxide, molecular biology of the enzymes generating these species, clinically useful biomarkers for evaluating oxidative stress status in humans, and the pathophysiology, clinical course and management of a variety of pediatric disorders, among others. The book also describes current diagnostic tools, laboratory methods and technology for treatment and prevention of pediatric disorders. It explores emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents.
Written by an international team of experts in both pediatrics and free radical and antioxidant research, Studies on Pediatric Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series.
Oxygen in health and disease.- Reactive oxygen species and nitric oxide in vascular function.- Nitrite pathway: Another important nitric oxide production system.- Nitric oxide and beyond: New insights and therapies for endothelial targeting.- Multifunctional roles of nitric oxide in neurons.- Oxidative stress biomarkers: Future perspectives.- Urinary clinical biomarkers in critical care.- Rapid diagnostic tests for oxidative stress status.- Analytical procedures for nitrative/nitrosative stress.- Animal models of enhanced oxidative stress.- Antioxidant supplementation and therapies.- Edaravone therapy.- Melatonin therapy.- Thioredoxin therapy.- Allergic and immunological disorders.- Cardiac disorders.- Environmental pollution and health consequences.- Gastrointestinal disorders.- Genetic disorders.- Growth, puberty and nutritional disturbances.- Hematologic disorders.- Infectious and inflammatory disorders.- Metabolic disorders.- Neurological disorders.- Renal disorders.- Respiratory disorders.- Trauma.- Vascular disorders.