Logo - springer
Slogan - springer

Life Sciences - Cell Biology | Moving Questions - A History of Membrane Transport and Bioenergetics

Moving Questions

A History of Membrane Transport and Bioenergetics

Robinson, Joseph D

Originally Published by Oxford University Press 1997

1997, 373 p.

eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

(net) price for USA

ISBN 978-1-4614-7600-9

digitally watermarked, no DRM

Included Format: PDF

download immediately after purchase


learn more about Springer eBooks

add to marked items

$119.00
  • About this book

  • Describes half a century of progress in two mainstream areas of biological research: membrane transport and oxidative phosphorylation
  • Written by leading researcher in the field
  • Provides a comprehensive history of membrane transport and bioenergetics
This book describes half a century of progress in two mainstream areas of biological research: membrane transport, initially a focus of physiologists, and oxidative phosphorylation, initially a focus of biochemists. Robinson shows how the development of new explanatory models had unexpectedly merged these inquiries into a new field, bioenergetics. In the late 1930s, explanations for the asymmetric distribution of ions between cells and their environments invoked absolute impermeabilities of the cell's surrounding membranes. But new experiments contradicted that idea and demonstrated that forming the transmembrane distributions required metabolic energy, implying the participation of active transport "pumps." Subsequent studies identified, isolated, and characterized these pumps as enzymes coupling ionic transport to the consumption of adenosine triphosphate (ATP), an "energy-rich" molecule serving as a cellular energy store. In the late 1930s oxidative phosphylation, the process of coupling ATP synthesis to oxidative metabolism, was identified. The explanatory model emerging in the next decades, however, did not follow the enzymatic precedents of known metabolic phosphorylations but rather embodied the principle that metabolic oxidations drive active transport pumps to create transmembrane distribution of ions, with these ionic asymmetries then driving ATP synthesis. It was discovered that ATP consumption can form ionic asymmetries; ionic asymmetries can drive ATP formation; and ionic asymmetries-like ATP-can also power other cellular functions.

Content Level » Professional/practitioner

Keywords » enzyme - membrane - membrane transport - metabolism - oxidative metabolism - physiology - skin - tissue

Related subjects » Cell Biology

Table of contents 

Introduction.- Views in the 1930s.- Accounting for Asymmetric Distributions of Na+ and K+ in Muscle.- Accounting for Asymmetric Distributions of Na+ and K+ in Red Blood Cells.- Ion Gradients and Movements in Excitable Tissues.- Epithelial Transport by Frog Skin.- Contemporary Events: 1939-1952.- Characterizing the Na+/K+ Pump.- Identifying the Na+/K+-ATPase.- Contemporary Events: 1953-1965.-Characterizing the Na+/K+-ATPase.-Structure and Relatives of the Na+/K+-ATPase.- Alternatives.- Using the Transmembrane Cation Gradients: Transporters and Channels.- Contemporary Events: 1966-1985.- Oxidative Phosphorylation: Chemical-Coupling Hypothesis.- Oxidative Phosphorylation: Chemiosmotic Coupling Hypothesis.- Oxidative Phosphorylation: F1, F0F1, and ATP Synthase.- Conclusions.

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Cell Physiology.