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Flow-Dependent Regulation of Vascular Function

  • Book
  • © 1995

Overview

Editors:
  1. John A. Bevan

    1. Department of Pharmacology, College of Medicine, University of Vermont, Burlington, USA

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  2. Gabor Kaley

    1. Department of Physiology, New York Medical College, Valhalla, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Gabor M. Rubanyi

    1. Berlex Biosciences, Richmond, USA

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  • Brings together research on the way in which blood flow can regulate vascular function
  • Particular emphasis is on vascular tone
  • Also examines the cellular and sub-cellular mechanisms involved, signal transduction systems, and role of flow-dependent mechanisms in various physiological regulating processes

Part of the book series: Clinical Physiology (CLINPHY)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
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  2. Biophysical and Biochemical Aspects

    1. Front Matter

      Pages 1-1
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    2. The Design of Fluid Transport Systems: A Comparative Perspective

      • Michael Labarbera
      Pages 3-27

    3. Shear Stress in the Circulation

      • Herbert H. Lipowsky
      Pages 28-45

    4. Flow-Mediated Signal Transduction in Endothelial Cells

      • Peter F. Davies
      Pages 46-61

    5. Gene Regulation in Endothelial Cells

      • Scott L. Diamond, Larry V. Mcintire
      Pages 62-84

    6. Flow Effects on Endothelial Cell Signal Transduction, Function, and Mediator Release

      • Francois Berthiaume, John A. Frangos
      Pages 85-116

  3. Flow-Mediated Control of Vascular Tone

    1. Front Matter

      Pages 117-117
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    2. Flow-Induced Vasodilation of Large Arteries: From “Ascending Reflex” to EDRF

      • Gabor M. Rubanyi
      Pages 119-127

    3. The Role of Flow-Induced Contraction and Relaxation in the Regulation of Vascular Tone: Results of In Vitro Studies

      • John A. Bevan
      Pages 128-162

    4. Coronary Microvascular Responses to Flow

      • Christopher J. H. Jones, Lih Kuo, Yuan Yuan, William M. Chilian, Michael J. Davis
      Pages 163-177

    5. Endothelium-Derived Relaxing Factor and the Control of Flow in Conduit and Resistance Arteries

      • Tudor M. Griffith
      Pages 178-213

    6. Regulation of Platelet Function by Flow-Induced Release of Endothelial Autacoids

      • Rudi Busse, Ingrid Fleming
      Pages 214-235

    7. Endothelial Control of Shear Stress and Resistance in the Skeletal Muscle Microcirculation

      • Akos Koller, Gabor Kaley
      Pages 236-260

    8. Overview of Regulatory Mechanisms in the Microcirculation

      • Paul C. Johnson, Vladimir Smieško
      Pages 261-273

  4. Flow-Induced Remodeling and Regulation of Vascular Function in Disease States

    1. Front Matter

      Pages 275-275
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    2. Blood Flow-Induced Remodeling of the Artery Wall

      • B. Lowell Langille
      Pages 277-299

    3. Atherosclerosis and the Role of Wall Shear Stress

      • Robert M. Nerem
      Pages 300-319

    4. Role of EDRF/NO in Chronic High Coronary Blood Flow States During Myocardial Dysfunction and Failure

      • Thomas H. Hintze, Jie Wang, Nahid Seyedi, Michael S. Wolin
      Pages 320-339

    5. Endothelial Role in Coronary Vasospasm and Atherosclerosis

      • Ian T. Meredith, Todd J. Anderson, Akimi Uehata, Alan C. Yeung, Thomas J. Ryan Jr., Andrew P. Selwyn et al.
      Pages 340-361
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Keywords

About this book

Exactly sixty years ago Schretzenmayer provided the first experimental proof that changes in blood ftow can affect the diameter oflarge arteries. Since then, support has been growing for the idea that intraluminal blood ftow plays an important role in regulating not only the tone of blood vessels, but also their caliber and structure. Investigations of the&e phenomena have been given a strong impetus by the discovery that the endothelium can modulate the tone of underlying vascular smooth muscle via the release of a number of vasoactive substances. Investigators often diverge in their opinions regarding the nature of the vascular wall response to blood ftow and the mechanisms involved. This book is the first summary of our state of knowledge and the nature of the research carried out on ftow-related changes. Early chapters review involvement of shear-stress-dependent events in the circulation as a whole. They cover the biophysical principles of ftuid transport, the cellular signal transduction path­ ways, and the molecular biology and biochemistry of ftow-induced changes in endothelial cells. Later chapters provide an in-depth summary of the regula­ tion of vascular muscle tone by ftow. They include historical perspectives, evi­ dence that ftow-induced vasodilation is primarily endothelium-dependent and that it can induce constriction, and details on ftow-dependent regulation in regional vascular beds. Several chapters emphasize the endothelial activation by shear stress and its importance in the control offtow in the microcirculation.

Editors and Affiliations

  • Department of Pharmacology, College of Medicine, University of Vermont, Burlington, USA

    John A. Bevan

  • Department of Physiology, New York Medical College, Valhalla, USA

    Gabor Kaley

  • Berlex Biosciences, Richmond, USA

    Gabor M. Rubanyi

Bibliographic Information

  • Book Title: Flow-Dependent Regulation of Vascular Function

  • Editors: John A. Bevan, Gabor Kaley, Gabor M. Rubanyi

  • Series Title: Clinical Physiology

  • DOI: https://doi.org/10.1007/978-1-4614-7527-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: American Physiological Society 1995

  • eBook ISBN: 978-1-4614-7527-9Published: 27 May 2013

  • Edition Number: 1

  • Number of Pages: 371

  • Additional Information: Originally Published by Oxford University Press 1995

  • Topics: Cell Physiology

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