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  • Book
  • © 2013

Studies on Arthritis and Joint Disorders

  • Describes the most current diagnostic tools, laboratory methods and technology
  • Provides specific coverage on emerging technology and medical applications
  • Promotes the concept of using biomarkers representative of oxidative stress reactions and free radical damage
  • Includes supplementary material: sn.pub/extras

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xii
  2. Biology of Oxidative Stress in Joint Disorders

    1. Front Matter

      Pages 1-1
    2. Soluble Proteomic Biomakers in the Management of Arthritis

      • Yves Henrotin, Ali Mobasheri
      Pages 3-31
    3. Regulation of T-Cell Functions by Oxidative Stress

      • Stuart J. Bennett, Helen R. Griffiths
      Pages 33-48
    4. Nitric Oxide and the Respiratory Chain in Synovial Cells and Chondrocytes

      • María J. López-Armada, Marta N. Valcárcel-Ares, Romina R. Riveiro-Naveira, Carlos Vaamonde-García
      Pages 49-66
    5. Adipokines, Molecular Players at the Crossroad Between Inflammation and Oxidative Stress: Role in Arthropathies

      • Morena Scotece, Javier Conde, Rodolfo Gómez, Verónica López, Francisca Lago, Juan J. Gómez-Reino et al.
      Pages 67-88
    6. Regulation of Cartilage and Bone Metabolism by Oxidative Stress

      • Anja Niehoff, Christoph Ziskoven
      Pages 89-108
    7. Role of Oxidative Stress in Bone Ageing

      • Sergio Portal-Núñez, Pedro Esbrit
      Pages 109-123
  3. Clinical Aspects of Oxidative Stress in Joint Disorders

    1. Front Matter

      Pages 125-125
    2. Genetic Component of Oxidative Stress in Rheumatoid Arthritis

      • F. David Carmona, Jose-Ezequiel Martin, Javier Martin
      Pages 127-143
    3. Oxidative Stress in Rheumatoid Arthritis

      • Katalin É. Szabó-Taylor, György Nagy, Paul Eggleton, Paul G. Winyard
      Pages 145-167
    4. Antioxidant and Antiinflammatory Properties of Heme Oxygenase-1 in Osteoarthritic Articular Cells

      • Maria Isabel Guillén, Isabel García-Arnandis, Victoria Clérigues, Javier Megías, Maria José Alcaraz
      Pages 199-222
    5. Metabolic Syndrome and Gout

      • Eswar Krishnan
      Pages 237-248
  4. Antioxidative Approach in Joint Disorders

    1. Front Matter

      Pages 249-249
    2. Antioxidants in the Treatment of Osteoarthritis and Bone Mineral Loss

      • Ali Mobasheri, Mehdi Shakibaei, Hans Konrad Biesalski, Yves Henrotin
      Pages 275-295
    3. Anti-cytokine Agents to Combat Oxidative Stress

      • Makoto Hirao, Jun Hashimoto, Norihiro Nishimoto
      Pages 297-309

About this book

This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress”, in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.

Reviews

From the reviews:

“This is a thorough overview of the role of oxidative damage in joint and connective tissue disease. This is a highly specialized area that is important for rheumatologists as well as for basic scientists to understand. … book is appropriate for all practitioners and academicians who are interested in the role of oxidative damage in joint disorders. … The authors do a great job of connecting basic science concepts with clinical disease. … easy to read, and diagrams and charts are clear and used appropriately.” (Jonathan Miner, Doody’s Book Reviews, July, 2013)

Editors and Affiliations

  • Fac Farmacia, Department of Pharmacology, University of Valencia, Valencia, Spain

    Maria Jose Alcaraz

  • , NEIRID Lab, Santiago University Clinical Hospital, Santiago de Compostela, Spain

    Oreste Gualillo

  • Fundación Jiménez Díaz Hospital, Rheumatology Division, Autonoma University, Madrid, Spain

    Olga Sánchez-Pernaute

About the editors

María José Alcaraz, Ph.D., is a full Professor in Pharmacology  at the Department of Pharmacology, University of Valencia, Spain, and former Head of this Department. After completing her Ph.D. at the University of Valencia with Extraordinary Award, she undertook postdoctoral research funded by the Spanish Ministery of Education at the Department of Pharmacology, King's Col. London (1983-1984).  She also worked as a visiting researcher at the Unité 348 INSERM, Paris (1998) and received  the Dr. Esteve Foundation Award to the best publication in pharmacology and Almirall Award to the best project in pharmacology.  In addition to act as editor or referee for several international journals and expert for scientific projects evaluation in different countries and international organizations,  she has played an active role in international cooperation with Latin America. Maria José Alcaraz is the head of the “Pharmacology of Inflammation” group, Department of Pharmacology, University of Valencia, Spain, which focuses on the pathogenesis of the inflammatory process, oxidative stress regulation and the development of new therapeutic targets for the treatment of joint diseases mainly rheumatoid arthritis and osteoarthritis.  

Dr. Oreste Gualillo obtained his PhD in Pharmacology at the Department of Experimental Pharmacology of the University “Federico II”, Naples (Italy). He received training in molecular endocrinology under Prof. Paul A. Kelly at the Necker School of Medicine, Paris. In 1998 he moved to the Laboratory of Molecular Endocrinology of the University of Santiago de Compostela, Spain, where he worked as a Marie Curie postdoctoral research fellow. In 2001 he set up his own research group at the Santiago University Clinical Hospital. He is currently a Class “A” Stable researcher with the SERGAS (Servizo Galegode Saude) and Carlos III Health Institute of the Spanish Ministry of Health, heading the NEIRID (NeuroEndocrine Interactions in Rheumatologyand Inflammatory Diseases) research laboratory of the Santiago University Clinical Hospital at the IDIS (Instituto de Investigación Sanitaria) of Santiago de Compostela. He has published over 80 papers and in the last years his research was focussed on defining the multifaceted role of adipokines in chondrocyte pathophysiology.

 

Olga Sánchez-Pernaute, MD, PhD, is a senior rheumatologist in the Jimenez Diaz Foundation University Hospital and assistant Prof at the Autonoma University School of Medicine in Madrid. She has a dilated background in translational research, focused on the study of innate mechanisms of disease associated to autoimmune rheumatic conditions. Of note are her early contributions to the field of inflammatory mediators in experimental models of arthritis, and the pioneer work on the role of fibrin in the progression of synovitis. She was invited for a one-year fellowship at the Laboratory of Experimental Rheumatology of Zürich University, where she developed her research interest in epigenetics. In the last few years she has created a Multidisciplinary Unit for Systemic Autoimmune Diseases that she currently directs at her Institution.

Bibliographic Information

Buy it now

Buying options

eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access