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Life Sciences - Cell Biology | Endocrine FGFs and Klothos

Endocrine FGFs and Klothos

Kuro-o, Makoto (Ed.)

2012, XX, 210p. 38 illus., 1 illus. in color.

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  • Discusses potential of FGF23 and Klotho as novel diagnostic markers and therapeutic targets for chronic kidney disease
  • Gives an overview of current knowledge on FGF19 and FGF21
  • Comprehensive in scope

Content Level » Research

Keywords » Endocrine - FGF - Fibroblast growth factor - Klotho - Kuro-o

Related subjects » Cell Biology - Human Genetics

Table of contents 

The Structural Biology of the FGF19 Subfamily.- Klotho and bKlotho.- FGF23 and Syndromes of Abnormal Renal Phosphate Handling.- Evidence For FGF23 Involvement in a Bone‑Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis.- FGF23, Klotho and Vitamin D Interactions: What Have We Learned from In Vivo Mouse Genetics Studies?.- FGF23 and the Parathyroid.- Regulation of Ion Channels by Secreted Klotho.- FGF23 in Chronic Kidney Disease.- Secreted Klotho and Chronic Kidney Disease.- FGF23 as a Novel Therapeutic Target.- Physiology of FGF15/19.- FGF19 and Cancer.- Understanding the Structure‑Function Relationship Between FGF19 and its Mitogenic and Metabolic Activities.- FGF21 as a Therapeutic Reagent.

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