The Red Cell Membrane

1. Front Matter

   Pages i-xx

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Why Red Cells?

      • H. J. Schatzmann

      Pages 3-17

   3. Need and Applications of Integrated Red Cell Models

      • Virgilio L. Lew, Carol J. Freeman, Olga E. Ortiz, Robert M. Bookchin

      Pages 19-34

3. Biochemistry and Biophysics

   1. Front Matter

      Pages 35-35

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   2. The Molecular Structure of the Na,K-ATPase

      • Lee Ann Baxter-Lowe, Lowell E. Hokin

      Pages 37-54

   3. Enzymatic and Functional Aspects of Na+/K+ Transport

      • Rhoda Blostein

      Pages 55-73

   4. The (Ca2+ + Mg2+)-ATPase

      • Basil D. Roufogalis, Antonio Villalobo

      Pages 75-101

   5. Catalytic Mechanisms of the Ca-Pump ATPase

      • Alcides F. Rega, Patricio J. Garrahan

      Pages 103-121

   6. Regulation of the Plasma Membrane Ca2+-Pump

      • Frank F. Vincenzi

      Pages 123-142

   7. The Anion Transport Protein

      • Michael L. Jennings

      Pages 143-170

   8. Kinetics of Anion Transport

      • Philip A. Knauf

      Pages 171-200

   9. Ca2+-Activated Potassium Channels

      • Javier Alvarez, Javier García-Sancho

      Pages 201-231

   10. Amino Acid Flux Across the Human Red Cell Plasma Membrane

       • Godfrey Tunnicliff

       Pages 233-247

   11. Hexose Transport Across Human Erythrocyte Membranes

       • Anthony Carruthers

       Pages 249-279

   12. Chloride-Dependent Cation Transport in Human Erythrocytes

       • Gordon W. Stewart, J. Clive Ellory

       Pages 281-302

4. Pharmacology

   1. Front Matter

      Pages 303-303

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   2. Pharmacological Modification of the Red Cell Ca2+-Pump

      • B. U. Raess

      Pages 305-327

   3. Irreversible Modification of the Anion Transporter

      • P. J. Bjerrum

      Pages 329-367

   4. Drug Actions on Potassium Fluxes in Red Cells

      • Balázs Sarkadi, George Gárdos

      Pages 369-396

"After being frequently urged to write upon this subject, and as often declining to do it, from apprehension of my own inability, I am at length compelled to take up the pen, however unqualified I may still feel myself for the task. " William Withering, M. D. ' I have yet to find a description or a quote that better summanzes my initial ambivalence towards embarking on such an endeavor as partici­ pating in putting together this monograph. The impetus for The Red-Cell has been a simple, genuine Membrane: A Model for Solute Transport desire to bring together an authoritative account of the' 'state of the art and knowledge" in the red-ceIl-membrane transport field. In particular, it seems important to emphasize the pivotal role the red cell has played for several decades in the discovery and the elucidation of mechanisms of plasma-membrane transport processes. It is only with such knowledge that we can hope to push ahead and make progress in this exciting, multifaceted area. Eventually, one hopes to not only further our knowledge of red cells, but apply the newly gained insights to any other of the plasma membrane. cell with the common denominator In this compendium of reviews, the reader will find that the term model will take on a variety of gists and meanings. In some chapters, the red cell has been chosen as a model membrane solely on the basis of its preeminent design and simplicity.

• Activation
• Malaria
• Regulation
• Vivo
• biochemistry
• blood cell
• erythrocyte
• liposomes
• pathophysiology
• physiology

• Department of Pharmacology and Toxicology, Indiana University School of Medicine, Evansville, USA

  B. U. Raess

• Department of Biochemistry, Indiana University School of Medicine, Evansville, USA

  Godfrey Tunnicliff

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