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Lysosomes

  • Book
  • © 2005

Overview

Authors:
  1. Paul Saftig

    1. Biochemisches Institut, Christian-Albrechts-Universität Kiel, Kiel, Germany

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  • Most up-to-date and comprehensive volume on lysosomal storage diseases available
  • Chapters written by leading experts in the field
  • Features chapters summaries and detailed illustrations

Part of the book series: Medical Intelligence Unit (MIUN)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xii
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  2. History and Morphology of the Lysosome

    • Renate Lüllmann-Rauch
    Pages 1-16

  3. Transport of Lysosomal Enzymes

    • Stephan Storch, Thomas Braulke
    Pages 17-26

  4. Adaptor Proteins in Lysosomal Biogenesis

    • Peter Schu
    Pages 27-36

  5. Lysosomal Membrane Proteins

    • Paul Saftig
    Pages 37-49

  6. Lysosomal Proteases

    • Klaudia Brix
    Pages 50-59

  7. Lysosomal Storage Disorders

    • Ole Kristian Greiner-Tollersrud, Thomas Berg
    Pages 60-73

  8. Lysosomal Transporters and Associated Diseases

    • Frans W. Verheijen, Grazia M. S. Mancini
    Pages 74-81

  9. Neuronal Ceroid-Lipofuscinoses

    • Jaana Tyynelä
    Pages 82-99

  10. Cholesterol Transport in Lysosomes

    • Judith Storch, Sunita R. Cheruku
    Pages 100-111

  11. Therapy of Lysosomal Storage Diseases

    • Ulrich Matzner
    Pages 112-129

  12. Lysosomal Proteome and Transcriptome

    • Jobst Landgrebe, Torben Lübke
    Pages 130-143

  13. External Lysosomes

    • Vincent Everts, Wouter Beertsen
    Pages 144-155

  14. Membrane Resealing Mediated by Lysosomal Exocytosis

    • Norma W. Andrews
    Pages 156-165

  15. Macroautophagy in Mammalian Cells

    • Eeva-Liisa Eskelinen
    Pages 166-180

  16. Chaperone-Mediated Autophagy

    • Erwin Knecht, Natalia Salvador
    Pages 181-193

  17. Back Matter

    Pages 195-197
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Keywords

About this book

Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.

This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy.

This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

Authors and Affiliations

  • Biochemisches Institut, Christian-Albrechts-Universität Kiel, Kiel, Germany

    Paul Saftig

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