Aging Research in Yeast

1. Front Matter

   Pages i-xii

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2. Introduction

   • Michael Breitenbach, Peter Laun, S. Michal Jazwinski

   Pages 1-12

3. Oxidative Stresses and Ageing

   • May T. Aung-Htut, Anita Ayer, Michael Breitenbach, Ian W. Dawes

   Pages 13-54

4. The Role of Mitochondria in the Aging Processes of Yeast

   • Michael Breitenbach, Peter Laun, J. Richard Dickinson, Andrea Klocker, Mark Rinnerthaler, Ian W. Dawes et al.

   Pages 55-78

5. The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging

   • S. Michal Jazwinski

   Pages 79-100

6. Chronological Aging in Saccharomyces cerevisiae

   • Valter D. Longo, Paola Fabrizio

   Pages 101-121

7. Aging and the Survival of Quiescent and Non-quiescent Cells in Yeast Stationary-Phase Cultures

   • M. Werner-Washburne, Sushmita Roy, George S. Davidson

   Pages 123-143

8. Maximising the Yeast Chronological Lifespan

   • Peter W. Piper

   Pages 145-159

9. Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae

   • John P. Aris, Laura K. Fishwick, Michelle L. Marraffini, Arnold Y. Seo, Christiaan Leeuwenburgh, William A. Dunn Jr.

   Pages 161-186

10. DNA Damage and DNA Replication Stress in Yeast Models of Aging

    • William C. Burhans, Martin Weinberger

    Pages 187-206

11. Yeast Aging and Apoptosis

    • Peter Laun, Sabrina Büttner, Mark Rinnerthaler, William C. Burhans, Michael Breitenbach

    Pages 207-232

12. Cellular Homeostasis in Fungi: Impact on the Aging Process

    • Christian Q. Scheckhuber, Andrea Hamann, Diana Brust, Heinz D. Osiewacz

    Pages 233-250

13. Genome-Wide Analysis of Yeast Aging

    • George L. Sutphin, Brady A. Olsen, Brian K. Kennedy, Matt Kaeberlein

    Pages 251-289

14. Genetic Approaches to Aging in Budding and Fission Yeasts: New Connections and New Opportunities

    • Bo-Ruei Chen, Kurt W. Runge

    Pages 291-314

15. Evolution of Asymmetric Damage Segregation : A Modelling Approach

    • Armin Rashidi, Thomas B.L. Kirkwood, Daryl P. Shanley

    Pages 315-330

16. Cellular Ageing and the Actin Cytoskeleton

    • David Amberg, Jane E. Leadsham, Vasillios Kotiadis, Campbell W. Gourlay

    Pages 331-352

17. Back Matter

    Pages 353-365

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This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

• Aging
• Cell Death
• Cell Quality Control
• Sacchromyces cerevisiae
• Yeast
• Apoptosis

From the reviews:

“This book compiles some of the most exciting and promising research to date in the fields of anti-aging, longevity, and possibly even rejuvenation. The authors’ research examines the role of senescence in yeast and how it may relate to the chaotic autophagy of cancer cells. In sum, Aging Research will stir interest in both scientific and non-scientific arenas.” (The Electric Review, October, 2012)

• , Department of Cell Biology, University of Salzburg, Salzburg, Austria

  Michael Breitenbach, Peter Laun

• , Tulane Center for Aging and Department o, Tulane University Health Sciences Center, New Orleans, USA

  S. Michal Jazwinski

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