2010, Approx. 270 p. 163 illus., 11 illus. in color.
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Introduces detailed protocols of IMS technology to visualize the spatial distributions of biomolecules present in biological tissues
Includes many illustrations and figures of tissue sections, instruments and analyses
Provides a basis for choosing an appropriate matrix and an overview of matrix application procedures
Addressing the widespread need for a practical guide to imaging mass spectrometry (IMS), this book presents the protocols of IMS technology. As that technology expands, research groups around the world continue its development. Pharmaceutical companies are using IMS for drug analyses to study pharmacokinetics and medical properties of drugs. Drug research and disease-related biomarker screening are experiencing greater use of this technology, with a concurrent increase in the number of researchers in academia and industry interested in wider applications of IMS. Intended for beginners or those with limited experience with IMS technology, this book provides practical details and instructions needed for immediate know-how, including the preparation of animal tissue samples, the application of a matrix, instrumental operations, and data analysis, among others. By describing the foundations of IMS, this volume contributes to the ongoing development of the field and to progress in human health.
Content Level »Research
Keywords »Mass Spectrometer - Mass Spectrometry - Microscope - biomolecules - drug - drug research - kinetics - microscopy - molecular imaging - pharmacokinetics - research - tissue