Aging of somatic stem cells reduces stem cell function and results in dysfunctional organs and tissues. Aging of stem cells is thus an underlying cause for aging associated diseases. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis like skin, blood, intestine. Understanding molecular and cellular mechanisms of aging of stem cells is critical for developing approaches to attenuate stem cell aging and it might pave avenues for a healthier life in the elderly. This book presents our current knowledge on mechanisms of aging of stem cells, written by highly prominent experts in the field. It gives insight into stem cell function, comprehensively explains the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches about how to attenuate stem cell aging or attain rejuvenation. The book is written for scientists and clinicians working with stem cells, on aging mechanism and age related diseases.
A) Introduction.- Stem cells, aging and longevity (overview).- General mechanisms of stem cell aging (overview).- Ying and Yang: extrinsic vs. intrinsic (overview).
B) Mechanisms of Stem Cell Aging in Model Organisms.-
Chronological aging.- Divisional aging.-
Primarily germline.- stem cell aging.-
Male germ line.- Female germ line.- Somatic stem cells (stress and regulation of hematopoietic precursors, intestinal stem cell aging and regulation).-
C) Mechanisms of Stem Cell Aging in Mammalian Tissues.-Hematopoietic (Mouse/Human).- Skin (Mouse/Human).- Intestine (Mouse/Human).- Muscle (Mouse/Human).- Neuronal Tissues (Mouse/Human).-
D) Diseases of Aging and Stem Cells.- Chronic Myeloid Leukemia and Aging of Hematopoietic Stem Cells (Mouse/Human).- Wound Healing Repair and Aging of Skin Stem Cells (Mouse/Human).-
E) Stem Cell Rejuvenation Muscle.- Hematopoietic.- Neuronal.-