The Science of Reconstructive Transplantation

1. Front Matter

   Pages i-xxi

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2. Introduction, History, and Clinical Impact

   1. Front Matter

      Pages 1-1

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   2. Reconstructive Transplantation: From Scientific Dream to Clinical Reality

      • Gerald Brandacher, Saami Khalifian, W.P. Andrew Lee

      Pages 3-11

   3. Clinical Pearls and Pitfalls in Reconstructive Transplantation

      • Huey Y. Tien, Yorell Manon-Matos, Tsu-Min Tsai, Christina L. Kaufman, Joseph E. Kutz

      Pages 13-31

   4. Reconstructive Transplantation: What Can We Learn from Solid Organ Transplantation?

      • Philip S. Brazio, Eduardo D. Rodriguez, Stephen T. Bartlett, Rolf N. Barth

      Pages 33-44

   5. The Daily Life of a Hand Transplant Recipient

      • Christopher Pollock

      Pages 45-49

3. Specific Areas of Research

   1. Front Matter

      Pages 51-51

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   2. Small Animal Models for Reconstructive Transplantation

      • Barbara Kern, Robert Sucher

      Pages 53-61

   3. Use of Large-Animal and Nonhuman Primate Models for Reconstructive Transplantation

      • Bruce Swearingen, Jeff Chang, David W. Mathes

      Pages 63-76

   4. Unique Immunological Features of Vascularized Composite Allografts

      • Kadiyala V. Ravindra

      Pages 77-90

   5. Immunological Similarities and Differences Between Extremity and Face Transplants

      • Palmina Petruzzo, Lionel Badet

      Pages 91-101

   6. Advances in Diagnosing Skin Rejection and Immune Monitoring

      • Emmanuel Morelon, Olivier Thaunat, Jean Kanitakis

      Pages 103-124

   7. Bayesian Classifier and Molecular Marker Platforms for Immune Monitoring

      • Rahul M Jindal, Kristin A Stevens, Jonathan A. Forsberg, Eric A. Elster

      Pages 125-132

   8. Migration and Communication Patterns in Skin Rejection

      • Johanna Grahammer, Theresa Hautz, Johann Pratschke, Stefan Schneeberger

      Pages 133-143

   9. Antibody-Mediated Rejection in Reconstructive Transplantation

      • Luis Landin, Pedro Bolado, Cesar Casado-Sanchez

      Pages 145-162

   10. Chronic Rejection in Reconstructive Transplantation

       • Christina L. Kaufman, Rosemary Ouseph, Joseph E. Kutz, Yorell Manon-Matos, Huey Y. Tien, Brenda Blair et al.

       Pages 163-179

   11. Cell-Based Immunomodulatory Concepts and Tolerance Protocols for Reconstructive Transplantation

       • Angelo A. Leto Barone, Victor W. Wong

       Pages 181-202

   12. Mixed Chimerism for Tolerance Induction of Vascularized Composite Allografts

       • David A. Leonard, Josef M. Kurtz, Curtis L. Cetrulo Jr.

       Pages 203-225

   13. Bone Marrow-Derived Ex Vivo Created Hematopoietic Chimeric Cells to Support Engraftment and Maintain Long-Term Graft Survival in Reconstructive Transplantation

       • Maria Siemionow, Joanna Cwykiel, Maria Madajka

       Pages 227-254

   14. Mesenchymal Stem Cells as Immune Modulators in VCA

       • Daniel J. Ceradini, Marc A. Soares

       Pages 255-275

This volume presents a comprehensive overview of the latest advances in basic and translational research in the field of reconstructive transplantation and its potential therapeutic implications. Dr. Thomas E. Starzl and Dr. Raimund Margreiter, both pioneers in the field of transplantation, have written the foreword for the book.

The volume spans such topics as skin rejection, immune monitoring, stem cell-based immunomodulatory strategies, costimulatory blockade, tolerance induction, chronic rejection, ischemia reperfusion injury, nerve regeneration, cortical reintegration, and small and large animal models for reconstructive transplantation. The book is intended for biomedical researchers and basic scientists in the field of reconstructive transplantation, transplant immunology and regenerative medicine, as well as clinicians, surgeons and multidisciplinary specialists, who are practicing or interested in this novel and exciting field. Postgraduate fellows and students will also find it a valuable reference.

• Composite allografts
• Immune monitoring
• Reconstructive transplantation
• Skin rejection
• Tissue engineering

• Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, USA

  Gerald Brandacher

Gerald Brandacher is Scientific Director of the Johns Hopkins Composite Tissue Allotransplantation (CTA) program. He is also an Associate Professor of surgery at the Department of Plastic and Reconstructive Surgery at Johns Hopkins University School of Medicine. Prior to joining Johns Hopkins in 2010, Dr. Brandacher was a Key Member of the hand transplant programs in Innsbruck, Austria, and at the University of Pittsburgh, where he headed the nation's first double hand transplant surgery and the first forearm transplant surgery. He was also instrumental in designing a novel cell-based immunomodulatory treatment protocol for CTA. His main scientific interests are donor-specific immune tolerance and immunomonitoring strategies and he has published extensively.

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