Overview
- Highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles
- Discusses possible ways endogenous regenerative potential might be manipulated for medical purposes
- Examines the endogenous reparative potential of the brain, including its limitations
Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Reviews
From the book reviews:
“A book of interest to researchers studying neurogenesis and regeneration and repair of the nervous tissue after injury. For neurologists, neurosurgeons and biologists.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (1), September, 2014)Editors and Affiliations
About the editors
Dr. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Children’s Hospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs.
Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies against these devastating cancers.
Bibliographic Information
Book Title: Endogenous Stem Cell-Based Brain Remodeling in Mammals
Editors: Marie-Pierre Junier, Steven G. Kernie
Series Title: Stem Cell Biology and Regenerative Medicine
DOI: https://doi.org/10.1007/978-1-4899-7399-3
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4899-7398-6Published: 09 February 2014
Softcover ISBN: 978-1-4899-7843-1Published: 23 August 2016
eBook ISBN: 978-1-4899-7399-3Published: 08 February 2014
Series ISSN: 2196-8985
Series E-ISSN: 2196-8993
Edition Number: 1
Number of Pages: VIII, 230
Number of Illustrations: 2 b/w illustrations, 19 illustrations in colour
Topics: Stem Cells, Cell Biology, Neurosciences, Neurochemistry, Cancer Research