Stem Cells: Current Challenges and New Directions

1. Front Matter

   Pages i-ix

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2. Myogenic Potential of Stem Cells: In Vivo Assessment

   • Maximilien Bencze, Ingo Riederer, Gillian S. Butler-Browne, Wilson Savino, Vincent Mouly

   Pages 1-17

3. Urine-Derived Stem Cells: Biological Characterization and Potential Clinical Applications

   • Guihua Liu, Chunhua Deng, Yuanyuan Zhang

   Pages 19-28

4. Immunoregulatory Properties of Mesenchymal Stem Cells: In Vitro and In Vivo

   • Pinar Çetinalp Demircan, Ayla Eker Sariboyaci, Erdal Karaoz

   Pages 29-58

5. Current Research on Stem Cells in Parkinson’s Disease: Progress and Challenges

   • Ria Thomas, Jan Pruszak

   Pages 59-84

6. Stem Cell Applications in Retinal Diseases

   • Güngör Sobacı

   Pages 85-103

7. Potential Use of Dental Stem Cells for Craniofacial Tissue Regeneration

   • Mustafa Ramazanoglu, Karl Andreas Schlegel, Gamze Torun Kose

   Pages 105-124

8. Pediatric Diseases and Stem Cells: Recent Advances and Challenges

   • Duygu Uçkan

   Pages 125-158

9. Stem Cell Therapy: From the Heart to the Periphery

   • Bernd Stratmann, Diethelm Tschoepe

   Pages 159-174

10. Stem Cells in Wound Healing

    • Dilek Telci, Ayca Zeynep Ilter, Merve Erdem

    Pages 175-197

11. Cancer Stem Cells: The Gist of the Matter

    • Torben Redmer, Dirk Schumacher, Wasco Wruck, Reinhold Schäfer, Christian R. A. Regenbrecht

    Pages 199-224

12. Filling the Gap in the Relationship Between Cancer and Stem Cells

    • Erdal Karaoz, Belma Akpinar

    Pages 225-251

13. Neural Stem Cells as Therapeutic Delivery Vehicles for Malignant Brain Tumors

    • Tugba Bagci-Onder

    Pages 253-278

14. Therapy Resistance in Prostate Cancer: A Stem Cell Perspective

    • Sandra Klein, Fiona M. Frame, Norman J. Maitland

    Pages 279-300

15. Mechanisms of Somatic Cell Reprogramming

    • Tamer T. Onder

    Pages 301-316

16. Disease Modeling and Drug Discovery Using Human Pluripotent Stem Cells

    • Christian Honoré, Mattias Hansson

    Pages 317-340

17. Stem Cell Research: Ethical Considerations

    • Berna Arda, Cemal Hüseyin Güvercin

    Pages 341-358

18. Back Matter

    Pages 359-373

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This volume looks at the state-of-the-science in stem cells, discusses the current challenges, and examines the new directions the field is taking. Dr. Turksen, editor-in-chief of the journal "Stem Cell Reviews and Reports," has assembled a volume of internationally-known scientists who cover topics that are both clinically and research-oriented. The contents range from sources of stem cells through their physiological role in health and disease, therapeutic applications in regenerative medicine, and ethics and society. An initial overview and a final summary bookend the contents into a cohesive and invaluable volume.

• Cancer therapy
• Cell based therapy
• Embryonic
• Hematopoiesis
• Mesenchymal
• Pluripotent stem cells

From the reviews:

“This is a compilation of review articles that presents current advances in different areas of research on stem cells and their clinical applications. … It is intended for individuals interested in the field of stem cell biology and regenerative medicine, among them scientists working in industry and academia, physicians and other healthcare professionals, and students of biomedical sciences. … This is a good overview of the directions and challenges in the quickly evolving field of stem cell biology.” (Joanna Goral, Doody’s Book Reviews, January, 2014)

• Regenerative Medicine Program, Ottawa Hospital Research Institute Sprott Centre for Stem Cell Research, Ottawa, Canada

  Kursad Turksen

Dr. Kursad Turksen is the Editor-in-Chief of the journal Stem Cell Reviews and Reports and the Stem Cell Biology and Regenerative Medicine book series, which are both published by Springer. He is also the Editor of numerous protocol volumes published in Springer’s Methods in Molecular Biology series. Dr. Turksen is a Senior Scientist at the Ottawa Hospital Research Institute, and his research interests cover the area of epidermal stem cells and the role of Claudins in the epidermal lineage.

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