Stem Cell Biology and Regenerative Medicine in Ophthalmology

1. Front Matter

   Pages i-xvi

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2. The Eye as a Target Organ for Stem Cell Therapy

   • Mark A. Fields, John Hwang, Jie Gong, Hui Cai, Lucian V. Del Priore

   Pages 1-29

3. Stem Cells in Oculofacial Plastic Surgery

   • Bryan J. Winn, Mary Whitman

   Pages 31-41

4. The Current Status of Corneal Limbal Stem Cell Transplantation in Humans

   • Roy S. Chuck, Alexandra A. Herzlich, Philip Niles

   Pages 43-56

5. Lens Differentiation from Embryonic Stem (ES) and Induced Pluripotent Stem (iPS) Cells

   • Ales Cvekl, Ying Yang, Yang Jing, Qing Xie

   Pages 57-73

6. Stem Cells and Glaucoma

   • Jonathan Hertz, Jeffrey L. Goldberg

   Pages 75-97

7. Bone Marrow Stem Cells in Retinal Disease

   • Louis K. Chang

   Pages 99-105

8. Stem Cells, Mechanism-Based Therapies and Regenerative Medicine Approaches

   • Xining He, Deniz Erol, Stephen H. Tsang

   Pages 107-120

9. New Developments in Retinal Cell Transplantation and the Impact of Stem Cells

   • Peter Gouras

   Pages 121-138

10. Cancer Stem Cells in Uveal Melanoma

    • Helen Kalirai, Bertil E. Damato, Sarah E. Coupland

    Pages 139-151

11. Current Ex-Vivo Gene Therapy Technologies and Future Developments

    • Chen-Hsien Su, Deniz Erol

    Pages 153-170

12. Stem Cell-Based Therapeutics in Ophthalmology: Application Toward the Design of Clinical Trials

    • Rony Gelman, Stephen H. Tsang

    Pages 171-178

13. Back Matter

    Pages 179-186

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Patient specific and disease specific stem cell lines have already introduced groundbreaking advances into the research and practice of ophthalmology. This volume provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to clinical genetics and regenerative treatments. Innovative results from stem cell research of the past decade are pointing the way toward practicable treatments for retinitis pigmentosa, age related macular degeneration, and Stargardt disease. What future directions will stem cell research take? Researchers, graduate students, and fellows alike will find food for thought in this insightful guide tapping into the collective knowledge of leaders in the field. Stem Cells in Ophthalmology is part of the Stem Cells in Regenerative Medicine series dedicated to discussing current challenges and future directions in stem cell research.

• ophthalmology
• regenerative medicine
• stem cell

• Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University, New York, USA

  Stephen H. Tsang

Stephen Tsang, MD, Ph.D. is an associate professor of Ophthalmology, Pathology and Cell Biology. Since 1992, he has been working on gene-targeting in stem cells and created the first gene-targeted model for a recessive form of retinitis pigmentosa with gene-targeting in embryonic stem cell technology; this model is used in current research by numerous laboratories. He received his M.D.-Ph.D. degrees from the NIH-National Institute of General Medical Sciences Medical Scientist Training Program (MSTP) at Columbia University. Dr. Tsang then completed his residency at Jules Stein Eye Institute/UCLA. Dr. Tsang's contributions to retinal degeneration research are known internationally and he is a member of the Fight-For-Sight grant-in-aid review panel for the last eight years. In his New York State supported stem cell program (N09G-302), we are examining embryonic stem (ES) cells to model and replace diseased human retinal cells. His skills are being recognized by the 2005 Bernard Becker-“Association of University Professor in Ophthalmology”-“Research to Prevent Blindness” Award. Dr. Tsang also participates in resident teaching and is the Columbia ophthalmology basic science course director. He is a member of the Macular Society. Named one of America’s Top Ophthalmologists in 2009, he has published over 60 research articles and lectured internationally on personalized medicine and stem cells in regenerative medicine.

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