Editors:
- Fills the gap of what has not been discussed in protein review and protocol books
- Includes supplementary material: sn.pub/extras
Part of the book series: Protein Reviews (PRON, volume 4)
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Table of contents (19 chapters)
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Front Matter
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Structural and Conformational Prerequisites of Amyloidogenesis
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The Generic Nature of Protein Folding and Misfolding
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Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation
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Cytotoxic Intermediates in the Fibrillation Pathway: Aβ Oligomers in Alzheimer’s Disease as a Case Study
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Glycosaminoglycans, Proteoglycans, and Conformational Disorders
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Apolipoproteins in Different Amyloidoses
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Oxidative Stress and Protein Deposition Diseases
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Chaperone and Conformational Disorders
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Front Matter
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The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation
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Protein Aggregation, Ion Channel Formation, and Membrane Damage
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Visualization of Protein Deposits In Vivo
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Front Matter
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Visualization of Protein Deposits In Vivo
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Visualization of Protein Deposits In Vivo
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Visualization of Protein Deposits In Vitro
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Front Matter
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Visualization of Protein Deposits In Vitro
About this book
This volume fills the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. It is devoted to the general questions of conformational disorders and includes discussion of involvement of such common factors as molecular chaperones, oxidative damage, proteasome, glycosoaminoglycans, serum amyloid protein P and several others in the development of different disorders. Some experimental techniques applicable for the visualization of protein deposition in vivo and in vitro are also present.
Editors and Affiliations
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Department of Biochemistry and Molecular Biology Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis
Vladimir N. Uversky
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Institute for Biological Instrumentation, Russian Academy of Sciences Pushchino, Moscow Region, Russia
Vladimir N. Uversky
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Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA
Anthony L. Fink
Bibliographic Information
Book Title: Protein Misfolding, Aggregation and Conformational Diseases
Book Subtitle: Part A: Protein Aggregation and Conformational Diseases
Editors: Vladimir N. Uversky, Anthony L. Fink
Series Title: Protein Reviews
DOI: https://doi.org/10.1007/b136464
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2006
Hardcover ISBN: 978-0-387-25918-5Published: 13 June 2006
Softcover ISBN: 978-1-4419-3851-0Published: 29 November 2010
eBook ISBN: 978-0-387-25919-2Published: 24 November 2007
Edition Number: 1
Number of Pages: XVIII, 419
Topics: Life Sciences, general, Immunology, Cell Biology