Urine Proteomics in Kidney Disease Biomarker Discovery

1. Front Matter

   Pages i-xiii

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2. Urine as Biomarker Source

   1. Front Matter

      Pages 1-1

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   2. Urine Is a Better Biomarker Source Than Blood Especially for Kidney Diseases

      • Youhe Gao

      Pages 3-12

   3. Urine Reflection of Changes in Blood

      • Menglin Li

      Pages 13-19

3. Urine Collection, Storage and Analysis

   1. Front Matter

      Pages 21-21

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   2. Urimem Facilitates Kidney Disease Biomarker Research

      • Liu Liu, Lulu Jia, Xuejiao Liu

      Pages 23-30

   3. Human Urine Proteome: A Powerful Source for Clinical Research

      • Lili Zou, Wei Sun

      Pages 31-42

   4. Exosomes in Urine Biomarker Discovery

      • Alyssa R. Huebner, Poorichaya Somparn, Thitima Benjachat, Asada Leelahavanichkul, Yingyos Avihingsanon, Robert A. Fenton et al.

      Pages 43-58

   5. Urinary Proteins with Post-translational Modifications

      • Liu Liu, Xuejiao Liu

      Pages 59-65

   6. Applications of Peptide Retention Time in Proteomic Data Analysis

      • Chen Shao

      Pages 67-75

   7. Urine Sample Preparation in 96-well Filter Plates to Characterize Inflammatory and Infectious Diseases of the Urinary Tract

      • Yanbao Yu, Rembert Pieper

      Pages 77-87

4. Factors That Changes Urinary Proteome

   1. Front Matter

      Pages 89-89

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   2. Variations of Human Urinary Proteome

      • Yong Chen

      Pages 91-94

   3. Evolution of the Urinary Proteome During Human Renal Development and Maturation

      • Zi Wang, Mingxi Li

      Pages 95-101

   4. Hormone-Dependent Changes in Female Urinary Proteome

      • Annalisa Castagna, Sarath Kiran Channavajjhala, Francesca Pizzolo, Oliviero Olivieri

      Pages 103-120

   5. Effects of Exercise on the Urinary Proteome

      • Maxie Kohler, Wilhelm Schänzer, Mario Thevis

      Pages 121-131

   6. Effects of Diuretics on Urinary Proteins

      • Xundou Li

      Pages 133-142

5. Discovery of Kidney Disease Biomarkers

   1. Front Matter

      Pages 143-143

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   2. Applications of Urinary Proteomics in Renal Disease Research Using Animal Models

      • Yang Lv, Guangyan Cai, Xiangmei Chen

      Pages 145-150

   3. The Application of Urinary Proteomics for the Detection of Biomarkers of Kidney Diseases

      • Song Jiang, Yu Wang, Zhihong Liu

      Pages 151-165

This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".

• kidney disease
• urine analysis
• urine and kidney biomarker
• urine collection
• urine exosome
• urine proteomics
• Proteomics

• Pathophysiology, Peking Union Medical College & Inst. Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China

  Youhe Gao

Youhe Gao is a professor from Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences. He is the member of the standing committee of the proteomics branch of the Chinese Society of Biochemistry and Molecular Biology. He was awarded the National Science Fund for Distinguished Young Scientists in 2007. His research is focused on human urine proteomics and its application, cell secretome and biological predication of protein-protein interaction.

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