Overview
- Gives a broad overview to the topic from chemical and biochemical basics to therapeutic application
- First volume on the topic with interdisciplinary scope
- Respective topics discussed by experts in basic science and clinical application
- Includes supplementary material: sn.pub/extras
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About this book
The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900’s. Three enzymes, cystathionine β–synthase (CBS), cystathionine γ–lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro. However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule. In the late 1980’s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S. Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured. However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues. H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases. This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Hydrogen Sulfide and its Therapeutic Applications
Editors: Hideo Kimura
DOI: https://doi.org/10.1007/978-3-7091-1550-3
Publisher: Springer Vienna
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Wien 2013
Hardcover ISBN: 978-3-7091-1549-7Published: 17 September 2013
Softcover ISBN: 978-3-7091-1974-7Published: 23 August 2016
eBook ISBN: 978-3-7091-1550-3Published: 02 September 2013
Edition Number: 1
Number of Pages: IX, 207
Number of Illustrations: 16 b/w illustrations, 23 illustrations in colour
Topics: Biochemistry, general, Medical Biochemistry, Pharmacology/Toxicology, Neurosciences