Logo - springer
Slogan - springer

Life Sciences - Biochemistry & Biophysics | Chromosome Segregation and Aneuploidy

Chromosome Segregation and Aneuploidy

Proceedings of the NATO Advanced Research Workshop on Chromosome Segregation and Aneuploidy, held at Aghia Pelagia, Greece, October 10-15, 1992

Series: Nato ASI Subseries H:, Vol. 72

Vig, Baldev K. (Ed.)

Softcover reprint of the original 1st ed. 1993, XVII, 425 pp.

Available Formats:

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.


(net) price for USA

ISBN 978-3-642-84938-1

digitally watermarked, no DRM

Included Format: PDF

download immediately after purchase

learn more about Springer eBooks

add to marked items


Softcover (also known as softback) version.

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.


(net) price for USA

ISBN 978-3-642-84940-4

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days

add to marked items

  • About this book

Aneuploidy - the greatest genetic affliction of man - has its origin in manycellular processes. Its forerunner, chromosome non-disjunction, can result from malfunction of one of many processes involved in faithful segregation of chromosomes during mitosis or meiosis. Experts on chromosome biology,centromere, kinetochore, microtubules, spindle apparatus, biochemistry of mitosis and meiosis, developmental biology, and environmental mutagenesis discuss basic and applied aspects of how chromosomes malsegregate and how aneuplody originates. The most recent techniques employed to study chromosome segregation and also methods to determine aneugenic chemicals are described.

Content Level » Research

Keywords » Aneuploidie - Chromosom - Chromosomensegregation - Kinetochor - Mutagenese - Zentromer - aneuploidy - biochemistry - cellular processes - centromere - chromosome segregation - developmental biology - kinetochore - mutagenesis

Related subjects » Biochemistry & Biophysics - Cancer Research - Cell Biology - Human Genetics - Oncology & Hematology

Table of contents 

Chromosome Segregation and Aneuploidy.- Structure of the Mammalian Centromere.- Properties of CENP-B and Its Target Sequence in Satellite DNA.- The Minor Satellite of Mouse and the Centromere.- Centromere Organization in Man and Mouse.- New Tools for the Study of Chromosome Segregation and Aneuploidy at the Molecular Level.- Premature Centromere Division and Other Centromeric Misbehaviour.- Genetic Approaches for Identifying Kinetochore Components in Saccharomyces Cerevisiae.- Cell Cycle Regulation of Centromere Function in Saccharomyces Cerevisiae.- Sensing DNA Damage: a Role for Chromosome Communication in Aneuploidy Induction.- The Acquisition and Association of TG1–3 Single-Strand Tails During Replication of Saccharomyces Telomeres.- Transposition as a Mechanism for Maintaining Telomere Length in Drosophila.- Molecular Features of Heterochromatin Condensation.- RCC1-Ran-RanGAP Signal for Initiation of Mitosis.- Implications of Cell Cycle Disturbances for Meiotic Aneuploidy: Studies on a Mouse Model System.- Morphogenesis of the Mitotic and Meiotic Spindle: Conclusions Obtained from One System Are Not Necessarily Applicable to the Other.- A Genetic Analysis of Microtubule Assembly and Function in Yeast.- The Events and Regulation of Anaphase Onset.- Microtubule Converging Centers — Implications for Microtubule Dynamics in Higher Plants.- Development of Kinetochores During Early Mitosis in HeLa Cells and the Stability of a Trilaminar Kinetochore Structure.- Are Topoisomerases Required for Mammalian Chromosome Segregation?.- Possible Targets for the Aneugenic Activity of Alkylating Agents.- The Relationship Between Chemically-Induced Meiotic Delay and Aneuploidy in Mouse Oocytes and Zygotes.- Correlation Between Induction of Meiotic Delay and Aneuploidy in Male Mouse Germ Cells.- Analysis of Micronuclei and Microtubule Arrangement to Identify Aneuploidy-Inducing Agents in Cultured Mammalian Cells.- Effects of Antitopoisomerase Drugs on Chromosome Recombination and Segregation in Grasshopper.- Disruption of Centromere Function by 2-Aminopurine.- Induction of Mitotic Aneuploidy in Lower Eukaryotes.- In Vivo Assay for Detection and Evaluation of Aneugens.- Multicolor Fluorescence in situ Hybridization with Centromeric DNA Probes as a New Approach to Distinguish Chromosome Breakage from Aneuploidy in Interphase Cells and Micronuclei.- The Detection, Definition and Regulation of Aneugenic Chemicals.

Popular Content within this publication 



Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Biochemistry.