Structure, Dynamics and Function of Biomolecules

1. Front Matter

   Pages I-XVI

   PDF

2. Introductory Keynotes

   1. The Nature of Mechanical Devices in Biological Systems

      • Robert J. P. Williams

      Pages 1-4

   2. Physical Chemistry and Biological Strategy of Antigen Recognition

      • Harden M. McConnell

      Pages 5-9

3. Structure and Dynamics of Heme Proteins

   1. Heme Protein Reactions: Models, Concepts, and Problems

      • Hans Frauenfelder

      Pages 10-14

   2. Multiple Conformational States of Myoglobin: A Molecular Dynamics Analysis

      • R. Elber, M. Karplus

      Pages 15-19

   3. Dynamics of Structural Changes in Hemoglobin

      • Eric R. Henry, James Hofrichter, William A. Eaton

      Pages 20-24

   4. Structure and Dynamics of Photodissociated Myoglobin

      • Denis L. Rousseau, Massimo Sassaroli, Siddharth Dasgupta

      Pages 25-29

   5. Structural Fluctuations in Myoglobin

      • F. Parak, H. Hartmann, G. U. Nienhaus, J. Heidemeier

      Pages 30-33

   6. Glass Transition of Hydration Water and Structural Flexibility of Myoglobin

      • Wolfgang Doster

      Pages 34-38

   7. Pressure Studies of Large-Scale Protein Motions

      • Robert D. Young

      Pages 39-42

   8. Viscosity and Glycerol Effects on Dynamics of Cytochrome c

      • Anders Ehrenberg

      Pages 43-46

   9. Kinetics of Geminate Recombination Following Photodissociation of Mutant (Carbonmonoxy)Hemoglobins

      • Marie-Pierre Fontaine, Lars Lindqvist

      Pages 47-50

4. Physical Aspects of Biomolecular Dynamics and Kinetics

   1. Thermodynamics of Enzyme Folding and Activity: Theory and Experiment

      • Chung F. Wong, J. Andrew McCammon

      Pages 51-55

   2. Progress and Problems in the Study of Protein Dynamics by X-Ray Diffraction

      • Gregory A. Petsko

      Pages 56-60

   3. Activation Free Energies of Enzymatic Reactions; Simulations and Experiments

      • Arieh Warshel

      Pages 61-64

   4. Simple Models for the Dynamics of Biomolecules: How Far Can We Go?

      • William Bialek, Robert F. Goldstein, Steven Kivelson

      Pages 65-69

   5. Condensed Matter Biophysics: Structure and Dynamics of Large Biomolecules

      • D. L. Stein

      Pages 70-74

   6. Molecular Dynamics Simulation of Parvalbumin in Aqueous Solution

      • Peter Ahlström, Olle Teleman, Bo Jönsson, Sture Forsén

      Pages 75-81

   7. Cooperative Ion Binding to Proteins. A Statistical Mechanical Approach

      • Peter Ahlström, Bo Jönsson, Clifford Woodward, Olle Teleman

      Pages 82-85

   8. Single Step Kinetics of Enzyme Dynamics

      • Pierre Douzou, Gaston Hui Bon Hoa

      Pages 86-92

This is a collection of papers presented and discussed at the first EBSA workshop held at Saltsj6baden outside stockholm in Sweden, July 6-10, 1986. The common theme of these papers is dynamics of biomolecules, and how the dynamics depends on the molecular structure and organi­ zation, and connects to and determines the biological function. This is a rapidly expanding field of research which combines many different aspects of molecular bio­ physics. Much material is new and presented for the first time. Even if the work so far has been of the kind that is usually called basic research, practical applications are clearly indicated in some articles, and are waiting around the corner in several other cases. At the workshop only one third of the time was used for the formal presentations and two thirds for discussion. To this should also be added discussions during the poster sessions. During these lively and unrecorded discussions fresh viewpoints emerged and new ideas were created. Ad­ mittedly, our knowledge at present is only fragmentary but when pieces of the puzzle are brought together at a workshop or in a publication of this kind more extended and sometimes unexpected contours and shapes become vi­ sible. It is our hope that this rapid publication of camera-ready manuscripts will transfer some of the spi­ rit at the workshop to the reader, and in his or her institute or laboratory initiate further discussions, bring forward more ideas and start new experimental ap­ roaches.

• ATPase
• Nucleotide
• X-ray
• base
• biomolecule
• biophysics
• electron microscopy
• enzymes
• ferritin
• kinetics
• magnetic resonance spectroscopy
• microscopy
• molecule
• spectroscopy
• thermodynamics

• Department of Biophysics Arrhenius Laboratory, University of Stockholm, Stockholm, Sweden

  Anders Ehrenberg, Astrid Gräslund

• Department of Medical Biophysics, Karolinska Institutet, Stockholm, Sweden

  Rudolf Rigler, Lennart Nilsson

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