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Reviews of Physiology, Biochemistry and Pharmacology

Special Issue on Cyclic GMP

  • Book
  • © 1999

Overview

Authors:
  1. G. Schultz
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  2. M. P. Blaustein
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  3. R. Greger
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  4. H. Grunicke
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  5. R. Jahm
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  6. W. J. Lederer
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  7. L. M. Mendell
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  8. A. Miyajima
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  9. D. Pette
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  10. M. Schweiger
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Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology (REVIEWS, volume 135)

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Table of contents (6 chapters)

  1. Front Matter

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  2. Mechanisms of regulation and functions of guanylyl cyclases

    • D. C. Foster, B. J. Wedel, S. W. Robinson, D. L. Garbers
    Pages 1-39

  3. Soluble guanylyl cyclase: Structure and regulation

    • D. Koesling, A. Friebe
    Pages 41-65

  4. Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)

    • D. M. Juilfs, S. Soderling, F. Burns, J. A. Beavo
    Pages 67-104

  5. Structure and function of cGMP-dependent protein kinases

    • A. Pfeifer, P. Ruth, W. Dostmann, M. Sausbier, P. Klatt, F. Hofmann
    Pages 105-149

  6. Structure and function of cyclic nucleotide-gated channels

    • M. Biel, X. Zong, A. Ludwig, A. Sautter, F. Hofmann
    Pages 151-171

  7. Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression

    • M. Eigenthaler, S. M. Lohmann, U. Walter, R. B. Pilz
    Pages 173-209
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Keywords

About this book

This special volume provides up-to-date information on research dealing with the regulation of the biosynthesis and degradation of cyclic GMP and with the regulation of physiological systems by cyclic GMP. The publication of this volume could not have come at a more appropriate time, with significant work in this area having led to our current understanding of the role of nitric oxide in signal transduction, and the 1998 Nobel Prize in Medicine and Physiology for Furchgott, Murad and Ignarro.
Moreover, the introduction in early 1998 of sildenafil (Viagra), a selective inhibitor of a cyclic GMP phosphodiesterase, for the treatment of erectile dysfunction in men represents the first successful therapeutic application of an agent designed to alter the activity of a molecular target in a cyclic GMP pathway.

Bibliographic Information

  • Book Title: Reviews of Physiology, Biochemistry and Pharmacology

  • Book Subtitle: Special Issue on Cyclic GMP

  • Authors: G. Schultz, M. P. Blaustein, R. Greger, H. Grunicke, R. Jahm, W. J. Lederer, L. M. Mendell, A. Miyajima, D. Pette, … M. Schweiger

  • Series Title: Reviews of Physiology, Biochemistry and Pharmacology

  • DOI: https://doi.org/10.1007/BFb0033667

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1999

  • Softcover ISBN: 978-3-662-31204-9Published: 23 August 2014

  • eBook ISBN: 978-3-540-68704-7Published: 11 December 2005

  • Series ISSN: 0303-4240

  • Series E-ISSN: 1617-5786

  • Edition Number: 1

  • Number of Pages: IX, 211

  • Number of Illustrations: 17 b/w illustrations, 27 illustrations in colour

  • Topics: Biochemistry, general, Cell Biology

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