Jointly published with Landes Bioscience, Georgetown, USA
1998, XIII, 229 p.
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This book provides a comprehensive, up-to-date review of the distribution, pharmacology and physiology of central 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes exhibit a unique pharmacology, distribution and function, of which the 5-HT4 receptor has been one of the most intensively studied in recent years, both from a basic research standpoint and as a target for novel therapeutics.
1. Medicinal Chemistry of 5-HT4 Receptor Ligands.- 2. Molecular Biology of 5-HT4 Receptors.- 3. Localization of 5-HT4 Receptors in Vertebrate Brain and Their Potential Behavioral Roles.- 4. Central 5-HT4 Receptors: Electrophysiology.- 5. Neurochemical Consequences Following Pharmacological Manipulation of Central 5-HT4 Receptors.- 6. 5-Hydroxytryptamine and Human Heart Function: The Role of 5-HT4 Receptors.- 7. 5-HT4 Receptors in Gastrointestinal Tract.- 8. 5-HT4 Receptors in Lower Urinary Tract Tissues.- 9. The 5-HT4 Receptor in the Adrenal Gland.- 10. Therapeutic Applications of 5-HT4 Receptor Agonists and Antagonists.