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"Comparative genomics is an exciting new field of bioinformatics dealing with problems of vital importance for many areas in biology. … This volume contains the 17 fully refereed papers presented at the fourth meeting, held in Montreal in September 2006. … I consider this book essential for libraries aiming to support research in any field of bioinformatics." (N. Sapidis, ACM Computing Reviews, Vol. 49 (4), April, 2008)