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Life Sciences - Biochemistry & Biophysics | Chemokines - Methods and Protocols

Chemokines

Methods and Protocols

Series: Methods in Molecular Biology, Vol. 1013

Cardona, Astrid E., Ubogu, Eroboghene E. (Eds.)

2013, XI, 238 p. 37 illus., 19 illus. in color.

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  • Features experimental models and state of the art protocols
  • Delineates chemokine/chemokine receptor function and their applications in health and disease
  • Includes key tips and expert implementation advice to ensure successful results

Chemokines constitute a large family of structurally similar cytokines that contain a signature of conserved cysteine residues joined by disulfide bridges.  Binding of chemokines to specific G protein-coupled receptors followed by downstream signaling defines their biological function.  Initially, chemoattraction was the key function linked to chemokines/chemokine receptors; however, in recent years, it has become clear that chemokine ligand-receptor interactions can also modulate cellular activation, survival, and proliferation, among other functions in homeostatic and diseased states.  Importantly, major advances in our understanding of chemokine biology have led to chemokine receptors becoming specific therapeutic targets with great potential.  In Chemokines: Methods and Protocols, expert researchers provide practical information regarding experimental models and state of the art protocols used to delineate chemokine/chemokine receptor function and their applications in health and disease.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 

Practical and easy to use, Chemokines: Methods and Protocols aims to reveal key protocols of functional and descriptive chemokine ligand/receptor assays that will be of practical significance to graduate students, post-doctoral fellows, trainees, and researchers in academia and industry.

Content Level » Professional/practitioner

Keywords » Chemokine function - Chemokine ligand - G protein-coupled receptors - Therapeutic targets

Related subjects » Biochemistry & Biophysics

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