Editors:
- Provides a collection of robust protocols for molecular biologists studying comparative genomics
- Each chapter includes detailed instructions for using a particular tool or method and an introduction to the theory behind the technique
- A Notes section at the end of each chapter that guides the user through commonly encountered difficulties, providing key tips for using the method most efficiently
Part of the book series: Methods in Molecular Biology (MIMB, volume 395)
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Table of contents (33 protocols)
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Front Matter
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Genome Visualization and Annotation
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Front Matter
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Sequence Alignments
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Front Matter
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Identification of Conserved Sequences and Biases in Codon Usage
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Front Matter
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About this book
Comparative Genomics, Volume 1, provides a collection of robust protocols for molecular biologists beginning to use comparative genomic analysis tools in a variety of areas. Volume I contains the first four of seven sections. In the first section, the reader is introduced to genomes via a number of visualization tools that allow one to browse through a particular genome of interest. The second and third sections deal with comparative analysis at the level of individual sequences, and present methods useful in sequence alignment, the discovery of conserved sequence motifs, and the analysis of codon usage. The fourth section deals with the identification and structural characterization of non-coding RNA genes — this class of genes is particularly difficult to predict, and discovery of these elements is almost completely reliant on comparative genomics. Given the tremendous increase in available biosequence data over the past ten years, Comparative Genomics, Volume 1, is timely, comprehensive, and novel. A companion Volume 2 is also available from Humana Press.
Editors and Affiliations
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Bioinformatics Program and Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor
Nicholas H. Bergman
Bibliographic Information
Book Title: Comparative Genomics
Book Subtitle: Volume 1
Editors: Nicholas H. Bergman
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-59745-514-5
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2008
Hardcover ISBN: 978-1-58829-693-1Published: 29 November 2007
Softcover ISBN: 978-1-61737-722-8Published: 25 December 2011
eBook ISBN: 978-1-59745-514-5Published: 29 June 2008
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIV, 546
Number of Illustrations: 144 b/w illustrations, 3 illustrations in colour
Topics: Biochemistry, general, Human Genetics, Cell Biology