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Life Sciences - Biochemistry & Biophysics | Microbial Gene Essentiality: Protocols and Bioinformatics

Microbial Gene Essentiality: Protocols and Bioinformatics

Series: Methods in Molecular Biology, Vol. 416

Osterman, Andrei L., Gerdes, Svetlana Y. (Eds.)

2008

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  • Offers a comprehensive, up-to-date collection of all the main strategies of experimental genome-scale gene essentiality analysis
  • Contains a detailed description of the procedures as well as a discussion of potential difficulties and failures
  • Includes chapters on statistical analysis of the generated datasets and their integration into existing genomic databases

Microbial Gene Essentiality: Protocols and Bioinformatics contains a comprehensive collection of experimental and computational strategies and techniques for microbial genome-scale essentiality studies, developed and presented by the leading groups in the field. In addition to wet-lab protocols, the book describes (i) statistical methods essential for planning successful large-scale essentiality screens, as well for data evaluation and analysis; (ii) in-silico prediction of gene essentiality using genome-scale reconstructed metabolic models; and (iii) data integration and comparative analysis in the context of genomic databases. This volume provides researchers with a first-stop guide for choosing the most appropriate strategy for planned essentiality studies. Experimental and computational aspects are equally important in genome-scale gene essentiality analysis, as in all other genomic technologies, and Microbial Gene Essentiality: Protocols and Bioinformatics reflects both of these aspects. All protocols follow the successful Methods in Molecular Biology™ series format, each offering an introduction outlining the principles behind the techniques, step-by-step instructions, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls, and are intended for both novice and expert scientists.

Content Level » Research

Keywords » Bur - Escherichia coli - Genomic databases - In-silico prediction - Metabolic models - Microarray - Microbial genome-scale essentiality - Mutant - Mutation - PCR - bioinformatics - chromosome - genes - hybridization - molecular biology

Related subjects » Biochemistry & Biophysics - Cell Biology - Human Genetics

Table of contents / Preface / Sample pages 

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Distribution rights for India: CBS Publishers, New Delhi, India

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