Overview
- Editors:
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Gerald Gübitz
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Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Graz, Austria
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Martin G. Schmid
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Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Graz, Austria
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Table of contents (25 protocols)
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Front Matter
Pages i-xiii
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- Gerald Gübitz, Martin G. Schmid
Pages 1-28
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- Kurt Günther, Peter Richter, Klaus Möller
Pages 29-59
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- Clifford R. Mitchell, Daniel W. Armstrong
Pages 61-112
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- Tom Ling Xiao, Daniel W. Armstrong
Pages 113-171
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- Chiyo Yamamoto, Yoshio Okamoto
Pages 173-181
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- Hassan Y. Aboul-Enein, Imran Ali
Pages 183-196
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- Myung Ho Hyun, Yoon Jae Cho
Pages 197-205
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- Peter Spégel, Lars I. Andersson, Staffan Nilsson
Pages 217-229
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- Leo Hsu, Genevieve Kennedy, Gerald Terfloth
Pages 247-253
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- Timothy J. Ward, Colette M. Rabai
Pages 255-263
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- Wioleta Maruszak, Martin G. Schmid, Gerald Gübitz, Elzbieta Ekiert, Marek Trojanowicz
Pages 275-289
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- Gunnar Johansson, Roland Isaksson, Göran Pettersson
Pages 307-315
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- Martin G. Schmid, Gerald Gübitz
Pages 317-321
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- Michael Lämmerhofer, Wolfgang Lindner
Pages 323-342
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About this book
Methods for enantiomer separation are very important for controlling synthesis, for checking racemization, for enantiomeric purity control, and for pharmacokinetic studies. In Chiral Separations: Methods and Protocols, prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotogrphic, gas chromatographic, and supercritical fluid chromatographic as well as recent electrochromotographic techniques. Each fully tested protocol includes an introduction to the principle underlying the method, equipment and reagent lists, and helpful notes on troubleshooting and avoiding known pitfalls.
Up-to-date and highly practical, Chiral Separations: Methods and Protocols will help both novice and advanced users not only choose optimal methods for their separation problems, but also readily obtain successful results.
Reviews
"It is an excellent book, and can be recommended for every laboratory involved in the synthesis and analysis of chiral compounds. Moreover, the editors have succeeded in getting internationally known leading experts to write the contributions." -Angewandte Chemie
"...will undoubtedly be of value to those who need to find useful ways to carry out such separations." -Journal of Medicinal Chemistry
"...this book is a useful compendium of chiral methods and will be of use to many workers in the field." - Biomed Chronatogr