The Enzyme Catalysis Process

1. Front Matter

   Pages i-ix

   PDF

2. Introductory Lectures

   1. Front Matter

      Pages 1-1

      PDF

   2. Enzyme Catalysis: An Overview from Physics

      • Giorgio Careri

      Pages 3-9

   3. Enzyme Catalysis: The View from Physical Chemistry

      • Alan Cooper, Julien L. Houben

      Pages 11-21

3. Protein Structure, Spectroscopy and Dynamics

   1. Front Matter

      Pages 23-23

      PDF

   2. Proteins: Interactions and Dynamics

      • R. L. Somorjai

      Pages 25-40

   3. Theories of Protein Folding

      • R. L. Somorjai

      Pages 41-53

   4. Structural and Functional Properties of Consecutive Enzymes in the Glycolytic Pathway

      • Herman C. Watson

      Pages 55-68

   5. The Spectroscopy of Enzymes: Introductory Remarks

      • J. L. Houben

      Pages 69-77

   6. Introduction to Vibrational Spectroscopy — From the Normal Mode to the Local Mode: Infrared, Raman and Inelastic Neutron Scattering

      • Francois Fillaux

      Pages 79-91

   7. Nonlinear Coupling and Vibrational Dynamics

      • Francois Fillaux

      Pages 93-102

   8. Low Frequency Dynamics of Proteins Studied by Inelastic Neutron Scattering

      • Stephen Cusack

      Pages 103-122

   9. The Fluorescence Properties of Aromatic Amino Acids: Their Role in the Understanding of Enzyme Structure and Dynamics

      • Arthur G. Szabo

      Pages 123-139

   10. The Application of 1H Nuclear Magnetic Resonance Spectroscopy to the Study of Enzymes

       • Christina Redfield

       Pages 141-158

   11. Thermodynamic Fluctuations and Function in Proteins

       • Alan Cooper, David T. F. Dryden

       Pages 159-171

   12. Using Resonance Raman Spectroscopy to Study the Structure and Dynamics of Enzyme-Bound Substrates

       • P. R. Carey

       Pages 173-195

   13. Structural Distributions, Fluctuations and Conformational Changes in Proteins Investigated by Mössbauer Spectroscopy and X-Ray Structure Analysis

       • Fritz Parak

       Pages 197-221

   14. Enzyme Hydration and Function

       • John A. Rupley, Giorgio Careri

       Pages 223-234

   15. Percolation Processes

       • John A. Rupley, Giorgio Careri

       Pages 235-246

   16. Statical and Dynamical Properties of Macromolecular Solutions

       • F. Wanderlingh, R. Giordano

       Pages 247-271

This volume represents the proceedings of a NATO Advanced Studies Instituteheld near Barga (Italy), July 11-23, 1988, involving over 90 participants from more than twelve countries of Europe, North America and elsewhere. It was not our intention at this meeting to present a complete up-to-the-minute review of current research in enzyme catalysis but t·ather, in accord wi th the intended spiri t of NATO ASis, to gi ve an opportunity for advanced students and researchers in a wide variety of disciplines to meet tagether and study the problern from different points of view. Hence the lectures cover topics rauging from the purely theoretical aspects of chemical reaction kinetics in condensed matter through practical experimental approaches to enzyme structure, dynamics and mechanism, including the new experimental opportunities arising from genetic engineering techniques. Our approachwas unashamedly physical, both because the more biochemical aspects of enzymology are amply covered elsewhere and because progress in our understanding and application of the molecular basis of enzymic processes must ultimately come from advances in physical knowledge. We tried to cover as wide a spectrum as possible, and succeeded in gathering an expert and enthusiastic team of speakers, but there . are some inevitable omissions. In particular, and with hindsight, our discussions might have been enriched by more detailed coverage of general aspects of chemical catalysis - but readers requiring this background should find adequate references herein.

• catalysis
• Chemical reaction
• enzyme
• enzymes
• kinetics
• reaction kinetics

• Dept. of Chemistry, University of Glasgow, Glasgow, Scotland, UK

  Alan Cooper

• Istituto di Chimica Quantistica ed Energetica Molecolare, CNR, Pisa, Italy

  Julien L. Houben, Lisa C. Chien

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