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The Enzyme Catalysis Process

Energetics, Mechanism and Dynamics

  • Book
  • © 1989

Overview

Editors:
  1. Alan Cooper

    1. Dept. of Chemistry, University of Glasgow, Glasgow, Scotland, UK

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  2. Julien L. Houben

    1. Istituto di Chimica Quantistica ed Energetica Molecolare, CNR, Pisa, Italy

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  3. Lisa C. Chien

    1. Istituto di Chimica Quantistica ed Energetica Molecolare, CNR, Pisa, Italy

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Part of the book series: NATO Science Series A: (NSSA)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introductory Lectures

    1. Front Matter

      Pages 1-1
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    2. Enzyme Catalysis: An Overview from Physics

      • Giorgio Careri
      Pages 3-9

    3. Enzyme Catalysis: The View from Physical Chemistry

      • Alan Cooper, Julien L. Houben
      Pages 11-21

  3. Protein Structure, Spectroscopy and Dynamics

    1. Front Matter

      Pages 23-23
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    2. Proteins: Interactions and Dynamics

      • R. L. Somorjai
      Pages 25-40

    3. Theories of Protein Folding

      • R. L. Somorjai
      Pages 41-53

    4. Structural and Functional Properties of Consecutive Enzymes in the Glycolytic Pathway

      • Herman C. Watson
      Pages 55-68

    5. The Spectroscopy of Enzymes: Introductory Remarks

      • J. L. Houben
      Pages 69-77

    6. Introduction to Vibrational Spectroscopy — From the Normal Mode to the Local Mode: Infrared, Raman and Inelastic Neutron Scattering

      • Francois Fillaux
      Pages 79-91

    7. Nonlinear Coupling and Vibrational Dynamics

      • Francois Fillaux
      Pages 93-102

    8. Low Frequency Dynamics of Proteins Studied by Inelastic Neutron Scattering

      • Stephen Cusack
      Pages 103-122

    9. The Fluorescence Properties of Aromatic Amino Acids: Their Role in the Understanding of Enzyme Structure and Dynamics

      • Arthur G. Szabo
      Pages 123-139

    10. The Application of 1H Nuclear Magnetic Resonance Spectroscopy to the Study of Enzymes

      • Christina Redfield
      Pages 141-158

    11. Thermodynamic Fluctuations and Function in Proteins

      • Alan Cooper, David T. F. Dryden
      Pages 159-171

    12. Using Resonance Raman Spectroscopy to Study the Structure and Dynamics of Enzyme-Bound Substrates

      • P. R. Carey
      Pages 173-195

    13. Structural Distributions, Fluctuations and Conformational Changes in Proteins Investigated by Mössbauer Spectroscopy and X-Ray Structure Analysis

      • Fritz Parak
      Pages 197-221

    14. Enzyme Hydration and Function

      • John A. Rupley, Giorgio Careri
      Pages 223-234

    15. Percolation Processes

      • John A. Rupley, Giorgio Careri
      Pages 235-246

    16. Statical and Dynamical Properties of Macromolecular Solutions

      • F. Wanderlingh, R. Giordano
      Pages 247-271
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Keywords

About this book

This volume represents the proceedings of a NATO Advanced Studies Instituteheld near Barga (Italy), July 11-23, 1988, involving over 90 participants from more than twelve countries of Europe, North America and elsewhere. It was not our intention at this meeting to present a complete up-to-the-minute review of current research in enzyme catalysis but t·ather, in accord wi th the intended spiri t of NATO ASis, to gi ve an opportunity for advanced students and researchers in a wide variety of disciplines to meet tagether and study the problern from different points of view. Hence the lectures cover topics rauging from the purely theoretical aspects of chemical reaction kinetics in condensed matter through practical experimental approaches to enzyme structure, dynamics and mechanism, including the new experimental opportunities arising from genetic engineering techniques. Our approachwas unashamedly physical, both because the more biochemical aspects of enzymology are amply covered elsewhere and because progress in our understanding and application of the molecular basis of enzymic processes must ultimately come from advances in physical knowledge. We tried to cover as wide a spectrum as possible, and succeeded in gathering an expert and enthusiastic team of speakers, but there . are some inevitable omissions. In particular, and with hindsight, our discussions might have been enriched by more detailed coverage of general aspects of chemical catalysis - but readers requiring this background should find adequate references herein.

Editors and Affiliations

  • Dept. of Chemistry, University of Glasgow, Glasgow, Scotland, UK

    Alan Cooper

  • Istituto di Chimica Quantistica ed Energetica Molecolare, CNR, Pisa, Italy

    Julien L. Houben, Lisa C. Chien

Bibliographic Information

  • Book Title: The Enzyme Catalysis Process

  • Book Subtitle: Energetics, Mechanism and Dynamics

  • Editors: Alan Cooper, Julien L. Houben, Lisa C. Chien

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4757-1607-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1989

  • Softcover ISBN: 978-1-4757-1609-2Published: 27 November 2013

  • eBook ISBN: 978-1-4757-1607-8Published: 11 December 2013

  • Edition Number: 1

  • Number of Pages: IX, 493

  • Topics: Biochemistry, general

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