Molecular Mechanisms of Metal Toxicity and Carcinogenesis

1. Front Matter

   Pages i-1

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2. Molecular mechanisms of metal toxicity and carcinogenesis

   1. Molecular mechanisms of metal toxicity and carcinogenesis

      • Suwei Wang, Xianglin Shi

      Pages 3-9

3. Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes

   1. Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes

      • Suyun Dong, Han-Ming Shen, Choon-Nam Ong

      Pages 11-20

4. Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2)exposed to cadmium chloride

   1. Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2)exposed to cadmium chloride

      • Paul Bernard Tchounwou, Ali Baba Ishaque, John Schneider

      Pages 21-28

5. Arsenic-induced NFKB transactivation through Erks-and JNKs-dependent pathways in mouse epidermal JB6 cells

   1. Arsenic-induced NFKB transactivation through Erks-and JNKs-dependent pathways in mouse epidermal JB6 cells

      • Chuanshu Huang, Jingxia Li, Min Ding, Liying Wang, Xianglin Shi, Vincent Castranova et al.

      Pages 29-34

6. Lead-related effects on rat fibroblasts

   1. Lead-related effects on rat fibroblasts

      • Iva Iavicoli, Alessandro Sgambato, Giovanni Carelli, Raffaele Ardito, Achille Cittadini, Nicolè Castellino

      Pages 35-40

7. In vivoreduction of chromium (VI) and its related free radical generation

   1. In vivo reduction of chromium (VI) and its related free radical generation

      • Ke Jian Liu, Xianglin Shi

      Pages 41-47

8. Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2)

   1. Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2)

      • Paul B. Tchounwou, Barbara A. Wilson, Ali B. Ishaque, John Schneider

      Pages 49-59

9. CombiningDrosophila melanogastersomatic-mutation-recombination and electron-spin-resonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity

   1. CombiningDrosophila melanogastersomatic-mutation-recombination and electron-spin-resonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity

      • Alan J Katz, Arthur Chiu, Jefferson Beaubier, Xianglin Shi

      Pages 61-68

10. Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cells

    1. Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cells

       • Nagalakshmi Keshava, Gu Zhou, Michelle Spruill, Mang Ensell, Tong-man Ong

       Pages 69-76

11. Cr (VI) induces cell growth arrest through hydrogen peroxide-mediated reactions

    1. Cr (VI) induces cell growth arrest through hydrogen peroxide-mediated reactions

       • Zhuo Zhang, Stephen S. Leonard, Suwei Wang, Val Vallyathan, Vince Castranova, Xianglin Shi

       Pages 77-83

12. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells

    1. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells

       • Show-Mei Chuang, Jia-Ling Yang

       Pages 85-95

13. Differential zinc and DNA binding by partial peptides of human protamine HP2

    1. Differential zinc and DNA binding by partial peptides of human protamine HP2

       • Wojciech Bal, Marcin Dyba, Zbigniew Szewczuk, Małgorzata Jeżowska-Bojczuk, Jan Lukszo, Gayatri Ramakrishna et al.

       Pages 97-106

14. Reduction of Cr (VI) by cysteine: Significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates

    1. Reduction of Cr (VI) by cysteine: Significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates

       • George Quievryn, Margarida Goulart, Joseph Messer Zhitkovich, Anatoly Zhitkovich

       Pages 107-118

15. Transactivation of RARE and GRE in the Cellular Response to Arsenic

    1. Transactivation of RARE and GRE in the Cellular Response to Arsenic

       • Chuanshu Huang, Jingxia Li, Min Ding, Max Costa, Vincent Castranova, Val Vallyathan et al.

       Pages 119-125

16. Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation

    1. Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation

       • Nadim J. Hallab, Katalin Mikecz, Csaba Vermes, Anastasia Skipor, Joshua J. Jacobs

       Pages 127-136

17. Arsenic contamination of groundwater and prevalence of arsenical dermatosis in the Hetao plain area, Inner Mongolia, China

    1. Arsenic contamination of groundwater and prevalence of arsenical dermatosis in the Hetao plain area, Inner Mongolia, China

       • Xiao juan Guo, Yoshihisa Fujino, Satoshi Kaneko, Kegong Wu, Yajuan Xia, Takesumi Yoshimura

       Pages 137-140

18. Involvement of Erks activation in cadmium-induced AP-1 transactivationin vitroandin vivo

    1. Involvement of Erks activation in cadmium-induced AP-1 transactivationin vitroandin vivo

       • Chuanshu Huang, Qunwei Zhang, Jingxia Li, Xianglin Shi, Vincent Castranova, Gong Ju et al.

       Pages 141-147

19. Chromium (vi)-induced oxidative stress, apoptotic Cell death and modulation of p53 tumor suppressor Gene

    1. Chromium (vi)-induced oxidative stress, apoptotic Cell death and modulation of p53 tumor suppressor Gene

       • Debasis Bagchi, Manashi Bagchi, Sidney J Stohs

       Pages 149-158

20. Review

    1. Carcinogenic metals and NF-κB activation

       • Fei Chen, Min Ding, Vince Castranova, Xianglin Shi

       Pages 159-171

During the last two decades, chemical and cellular studies have contributed enormously to our understanding of metal-induced carcinogenesis, and many hypotheses on the role of metals in pathophysiological processes have been investigated. In addition, new techniques are available to shed light on the mechanism of carcinogenesis in molecular terms. This conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis in September 2000 focused on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.

• DNA
• apoptosis
• carcinoma
• gene expression
• transcription

• Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, USA

  Xianglin Shi, Vince Castranova, Val Vallyathan

• Occupational Safety and Health Administration, Washington DC, USA

  William G. Perry

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