Overview
- Editors:
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Lawrence J. Berliner
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The Ohio State University, Columbus, USA
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Table of contents (11 chapters)
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Structure
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- Wolfram Bode, Robert Huber, Timothy J. Rydel, Alexander Tulinsky
Pages 3-61
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- Feng Ni, Kenneth D. Gibson, Harold A. Scheraga
Pages 63-85
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Biochemistry
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Front Matter
Pages 115-115
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- James C. Powers, Chih-Min Kam
Pages 117-158
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- Steven T. Olson, Ingemar Björk
Pages 159-217
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- Stuart R. Stone, John M. Maraganore
Pages 219-256
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Physiology
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Front Matter
Pages 273-273
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- Rachel Bar-Shavit, Miriam Benezra, Valerie Sabbah, Elisabetta Dejana, Israel Vlodavsky, George D. Wilner
Pages 315-350
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- Joe G. N. Garcia, Judy L. Aschner, Asrar B. Malik
Pages 397-430
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Back Matter
Pages 431-438
About this book
Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombin topic areas: Structure, Biochemistry, and Physiology. In Part 1, Structure, we open with the complete three-dimensional x-ray structures of two inhibited human thrombin complexes, one of which is the thrombin-hirudin com plex. These complexes are also addressed in the chapter on structural studies in solution, which include NMR, ESR, and fluorescence. Part 2, Biochemistry, includes chapters on synthetic thrombin inhibitors, protein inhibitors (e.g., antithrombin III, hirudin), and thrombin interactions with factor XIII. Part 3, Physiology, covers such topics as chemotactic activities, interactions with cell surfaces, and the vascular endothelium.
Editors and Affiliations
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The Ohio State University, Columbus, USA
Lawrence J. Berliner
About the editor
Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.
