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Proteases in the Brain

  • Book
  • © 2005

Overview

Editors:
  1. Uwe Lendeckel

    1. Otto-von-Guericke University, Magdeburg, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Nigel M. Hooper

    1. University of Leeds, Leeds, UK

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    You can also search for this editor in PubMed   Google Scholar

  • Of interest for both advanced researchers/neurologists as well as for students of biology and medicine
  • Brings together a wide range of topics under one central theme

Part of the book series: Proteases in Biology and Disease (PBAD, volume 3)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Proteases and Alzheimer’s Disease: Present Knowledge and Emerging Concepts of Therapy

    • Hans-Gert Bernstein
    Pages 1-23

  3. Calpain Proteolysis and the Etiology of Parkinson’s Disease: An Emerging Hypothesis

    • Stephen J. Crocker, Patrice D. Smith, David S. Park
    Pages 25-61

  4. Cysteine Proteases in Neuronal Death in Brain Ischemia

    • Swapan K. Ray
    Pages 63-77

  5. Proteases in Traumatic Brain Injury

    • Susan M. Knoblach, Alan I. Faden
    Pages 79-108

  6. Proteases in CNS Infection and Inflammation

    • Bernd C. Kieseier, Fabian Bernal
    Pages 109-137

  7. Dipeptidyl Peptidase IV Regulates T Cell Function in CNS Inflammation

    • Stefan Brocke, Andreas Steinbrecher, Aliza Bitonl, Maya Ratner, Vera Preller, Bettina Rotthauwe et al.
    Pages 139-150

  8. Role and Regulation of Proteases in Human Glioma

    • Sajani S. Lakka, Jasti S. Rao
    Pages 151-177

  9. Proteases and Prion Diseases

    • M. Antonieta Valenzuela, Luis Cartier, Aron D. Mosnaim, Marion E. Wolf, Ana María Kettlun, Lucía Collados et al.
    Pages 179-202

  10. Neuropeptide Processing

    • Mathias Hallberg, Pierre Le Grevès, Fred Nyberg
    Pages 203-234

  11. Proteases and Neuronal Plasticity

    • John W. Wright, Joseph W. Harding
    Pages 235-270

  12. Serine Proteases and Neuronal Plasticity in vivo

    • Nobuko Mataga, Takao K. Hensch
    Pages 271-301

  13. Proteases and Synaptic Activity

    • Hiroshi Nakanishi
    Pages 303-322

  14. Role of Proteinase-Activated Receptors in Brain Function

    • Barry W. Festoff
    Pages 323-350

  15. Matrix Metalloproteinases and Neuroinflammation in Multiple Sclerosis

    • Corey C. Ford, Gary A. Rosenberg
    Pages 351-371

  16. Back Matter

    Pages 373-383
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Keywords

About this book

In all organs of the body, proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumor progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes.

Proteases in the Brain reviews the role and regulation of proteases in, Alzheimer’s disease, brain ischemia and traumatic brain injury, human glioma, inflammatory and infectious diseases of the central nervous system, metabolism of the prion protein, modulating synaptic activity, multiple sclerosis, neuronal plasticity and memory consolidation, Parkinson’s disease, processing, conversion and inactivation of neuropeptides.

Proteases in the Brain is a timely and useful source of information both for those well-versed in the role of proteases in the brain, and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction.

Editors and Affiliations

  • Otto-von-Guericke University, Magdeburg, Germany

    Uwe Lendeckel

  • University of Leeds, Leeds, UK

    Nigel M. Hooper

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