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In all organs of the body proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumour progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes.
Proteases in the Brain reviews the role and regulation of proteases in
brain ischemia and traumatic brain injury
inflammatory and infectious diseases of the central nervous system
metabolism of the prion protein
modulating synaptic activity
neuronal plasticity and memory consolidation
processing, conversion and inactivation of neuropeptides.
Proteases in the Brain is a timely and useful source of information both for those well versed in the role of proteases in the brain and for those who are beginning to realize the important role of this family of enzymes in brain function and dysfunction.
Chapter 1 Proteases and Alzheimer Disease: Present Knowledge and Emerging Concepts of Therapy Hans-Gert Bernstein Chapter 2 Calpain Proteolysis and the Etiology of Parkinson’s Disease: An Emerging Hypothesis Stephen J. Crocker, Patrice D. Smith and David S. Park Chapter 3 Cysteine Proteases in Neuronal Death in Brain Ischemia Swapan K. Ray Chapter 4 Proteases in Traumatic Brain Injury Susan M. Knoblach and Alan I. Faden Chapter 5 Proteases in CNS Infection and Inflammation Bernd C. Kieseier and Fabian Bernal Chapter 6 Dipeptidyl Peptidase IV Regulates T Cell Function in CNS Inflammation Stefan Brocke, Andreas Steinbrecher, Aliza Biton, Maya Ratner, Vera Preller, Bettina Rotthauwe, Sabine Wrenger and Dirk Reinhold Chapter 7 Role and Regulation of Proteases in Human Glioma Sajani S. Lakka and Jasti S. Rao Chapter 8 Proteases and Prion Diseases M. Antonieta Valenzuela, Luis Cartier, Aron D. Mosnaim, Marion E. Wolf, Ana María Kettlun, Lucía Collados, Lorena García Chapter 9 Neuropeptide Processing Mathias Hallberg, Pierre Le Grevès and Fred Nyberg Chapter 10 Proteases and Neuronal Plasticity John W. Wright and Joseph W. Harding Chapter 11 Serine Proteases and Neuronal Plasticity in vivo Nobuko Mataga and Takao K. Hensch Chapter 12 Proteases and Synaptic Activity Hiroshi Nakanishi Chapter 13 Role of Proteinase-Activated Receptors in Brain Function Barry W. Festoff Chapter14 Matrixmetalloproteinases and Neuroinflammation in Multiple Sclerosis Corey C. Ford and Gary W. Rosenberg Index