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Proteases in Tissue Remodelling of Lung and Heartis unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data.
Proteases in Tissue Remodelling of Lung and Heart: *is devoted to proteases in lung and heart specifically and extensively, *covers major diseases of the lung and heart, *extensively introduces individual proteases (or families thereof), *presents up-to-date patient-derived and experimental data, *covers most aspects of protease function in disease.
Part I: Lung.
1. Human leukocyte elastase and cystic fibrosis; A.M. Cantin, A. Fournier, R. Leduc. 2. Matrix metalloproteinases in inflammation of the lung; Y. St-Pierre, C. Van Themsche. 3. Proteases in interstitial lung diseases; A. Wille, T. Welte, F. Bühling. 4. Matrix metalloproteinase inhibitors in cancer therapy; W. T. Purcell, M. Hidalgo. 5. The role of proteases in the pathogenesis of lung emphysema; H. Golpon, T. Köhnlein, T. Welte.
Part II: Heart.
6. Cardiac remodeling in pressure overload hypertrophy; U. Seeland, M. Böhm. 7. Ischemia / myocardial infarction: The role of matrix metalloproteinases; T. Takahashi, R.T. Lee. 8. Matrix metalloproteinases and myocardial remodeling in heart failure; Yun You Li, A.M. Feldman. 9. Proteases and arrhythmias; A. Goette, C. Röcken, K. Nepple, U. Lendeckel. 10. Impact of proteases in tissue engineering and regeneration; H. Mertsching, C. Puschman.