Phospholipid Metabolism in Apoptosis

1. Front Matter

   Pages i-xvi

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2. Lipid Metabolism and Release of Cytochrome c from Mitochondria

   • Volker Lehmann, Vladimir Shatrov

   Pages 1-17

3. Interaction Between Cytochrome c and Oxidized Mitochondrial Lipids

   • Yoshihiro Shidoji, Sadaaki Komura, Nobuko Ohishi, Kunio Yagi

   Pages 19-37

4. Plasma Membrane Phospholipid Asymmetry

   • Peter J. Quinn

   Pages 39-60

5. Apoptosis by Phosphatidylserine in Mammalian Cells

   • Kazuo Emoto, Masato Umeda

   Pages 61-77

6. Phosphatidylserine Peroxidation During Apoptosis

   • Y. Y. Tyurina, V. A. Tyurin, S. X. Liu, C. A. Smith, A. A. Shvedova, N. F. Schor et al.

   Pages 79-96

7. Role of Nitric Oxide and Membrane Phospholipid Polyunsaturation in Oxidative Cell Death

   • C. Patrick Burns, Eric E. Kelley, Brett A. Wagner, Garry R. Buettner

   Pages 97-121

8. Oxidized LDL-Induced Apoptosis

   • Hervé Benoist, Robert Salvayre, Anne Nègre-Salvayre

   Pages 123-150

9. Induction of Apoptosis by Redox-Cycling Quinones

   • Karin Öllinger, Katarina Kågedal

   Pages 151-170

10. Apoptosis Induced by Ionizing Radiation

    • Cristiano Ferlini, Raffaele D’ Amelio, Giovanni Scambia

    Pages 171-186

11. Ceramidases in the Regulation of Ceramide Levels and Function

    • Samer El Bawab, Cungui Mao, Lina M. Obeid, Yasuf A. Hannun

    Pages 187-205

12. Effect of Ceramides on Phospholipid Biosynthesis and Its Implication for Apoptosis

    • Arie B. Vaandrager, Martin Houweling

    Pages 207-227

13. Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis

    • Erich Gulbins, Richard Kolesnick

    Pages 229-244

14. Cellular Signaling by Sphingosine and Sphingosine 1-Phosphate

    • Susan Pyne

    Pages 245-268

15. Ceramide in Regulation of Apoptosis

    • Jean-Pierre Jaffrézou, Guy Laurent, Thierry Levade

    Pages 269-284

16. Lipid Signaling in CD95-mediated Apoptosis

    • Alessandra Rufini, Roberto Testi

    Pages 285-308

17. Phosphatidylinositol 3-kinase, Phosphoinositides and Apoptosis

    • Gabriella Sarmay

    Pages 309-333

18. Back Matter

    Pages 335-340

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The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. The number of publications on the topic has increased from nothing in the early 1980s to more than 10,000 papers annually today. It is now well recognized that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The idea that life requires death seems somewhat paradoxical, but cell suicide is essential for an animal to survive. For example, without selective destruction of “non-self” T cells, an animal would lack immunity. Similarly, meaningful neural connections in the brain are whittled from a mass of cells. Further, developmental cell remodeling during tissue maturation involves programmed cell death as the major mechanism for functional and structural safe transition of undifferentiated cells to more specialized counterparts. Apoptosis research, with roots in biochemistry, developmental and cell biology, genetics, and immunology, embraces this long-ignored natural law. Failure to properly regulate apoptosis can have catastrophic consequences. Cancer and many diseases (AIDS, Alzheimer’s disease, Parkinson’s disease, heart attack, stroke, etc. ) are thought to arise from deregulation of apoptosis. As apoptosis emerges as a key biological regulatory mechanism, it has become harder and harder to keep up with new developments in this field.

• Lipid
• Oxidation
• biosynthesis
• metabolism
• molecular mechanisms
• regulation

• Kings College London, London, UK

  Peter J. Quinn

• University of Pittsburgh, Pittsburgh

  Valerian E. Kagan

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