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Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.
Preface. Basic Mechanisms. Delineation of the Pathogenesis of Systemic Lupus Erythematosus by Using Murine Models; K. Liu, E.K. Wakeland. Factors Contributing to Autoimmune Disease; K.M. Garza, et al. Control of Autoimmunity by Regulatory T Cells; E.M. Shevach, et al. Autoimmunity, Self-Tolerance, and Immune Homeostasis: From Whole Animal Phenotypes to Molecular Pathways; C.C. Goodnow, et al. Peripheral Tolerance and Organ Specific Autoimmunity; H. von Boehmer, E. Jaeckel. Autoimmune Lymphoproliferative Syndrome: Types I, II, and Beyond; H.J. Chun, M.J. Lenardo. Pathogenesis. The Role of MHC Class II Molecules in the Pathogenesis and Prevention of Type I Diabetes; H. McDevitt. Control of Autoreactive T Cell Activation by Immunoregulatory T Cells; J.-F. Bach. Immune Tolerance and The Nervous System; D.E. Anderson, D.A. Hafler. Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demyelinating Diseases; S.D. Miller, T.N. Eager. Therapy. Multiple Sclerosis and Gene Expression Profiling; L. Steinman. Treatment of Autoimmunity by Inhibition of T Cell Costimulation; D.I. Daikh, D. Wofsy. Cytokine Blockade in Rheumatoid Arthritis; M. Feldmann, et al. Index.