Protein Synthesis and Targeting in Yeast

1. Front Matter

   Pages I-XV

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2. mRNA Stability and Translation

   1. Identification of the cis-acting sequences and trans-acting factors involved in nonsense-mediated mRNA decay

      • Stuart W. Peltz, Christopher Trotta, He Feng, Agneta Brown, Janet Donahue, Ellen Welch et al.

      Pages 1-10

   2. RNA14 and RNA15, Two Proteins Regulating mRNA Stability in Saccharomyces Cerevisiae

      • A. Petitjean, L. Minvielle-Sebastia, E. Mandart, N. Bonneaud, F. Lacroute

      Pages 11-18

   3. Translational Control in Saccharomyces Cerevisiae Studies In Vivo and In Vitro

      • J. E. G. McCarthy, B. Gerstel, M. R. Vega Laso, D. Zhu, M. F. Tuite, F. Sagliocco et al.

      Pages 19-28

3. The Ribosome

   1. Thoughts on the Regulation of Ribosome Synthesis in Saccharomyces Cerevisiae

      • J. R. Warner

      Pages 29-38

   2. Regulation of Ribosomal Protein Synthesis in Yeasts (Saccharomyces and Kluyveromyces)

      • Rudi J. Planta, Ruurdtje Hoekstra, G. Karin Bergkamp-Steffens, Paula M. Gonçalves, Willem H. Mager

      Pages 39-51

   3. The Evolution of Ribosomal Proteins and Yeast

      • E. Otaka, T. Hashimoto, K. Mizuta, K. Suzuki

      Pages 53-66

   4. The Acidic Ribosomal Proteins and the Control of Protein Synthesis in Yeast

      • J. P. G. Ballesta, M. Remacha, T. Naranda, C. Santos, B. Bermejo, A. Jimenez-Diaz et al.

      Pages 67-80

4. Translational Fidelity

   1. SUP35 and SUP45 Genes Code for Ribosome-Bound Proteins Involved in the Control of Translational Fidelity in Yeast

      • Michael D. Ter-Avanesyan, Svetlana A. Didichenko, Vitaly V. Kushnirov, Adilya R. Dagkesamanskaya

      Pages 81-90

   2. Mutations Affecting Translational Accuracy in Yeast

      • Susan W. Liebman, Annette Vincent, Jae Mahn Song, Jamie All-Robyn

      Pages 91-100

   3. Dosage-Dependent Modifiers of Psi-Dependnet Omnipotent Suppression in Yeast

      • Yury O. Chernoff, Bunichiro Ono

      Pages 101-110

   4. Aberrant mRNA Decoding in the Dimorphic Yeast Candida Albicans

      • Manuel A. Santos, Gerad Keith, Mick F. Tuite

      Pages 111-121

5. Translation Factors

   1. Effect of Initiation Factor eIF-5A Depletion on Cell Proliferation and Protein Synthesis

      • Hyun Ah Kang, Hubert G. Schwelberger, John W. B. Hershey

      Pages 123-129

   2. Analysis of the genes encoding eIF-4A from yeast

      • Stefanie R. Schmid, Peter Buser, Raffaella Coppolecchia, Andrea Fischli, Patrick Linder

      Pages 131-142

   3. Uncharged tRNA and Derepression of the General Amino Acid Control: Autoregulation of Yeast Lysyl-tRNA Synthetase

      • Stefan Lanker, Janet L. Bushman, Alan G. Hinnebusch, Hans Trachsel, Peter P. Mueller

      Pages 143-155

6. Translation in the Mitochondrion

   1. Positive Control of Translation in Organellar Genetic Systems

      • Thomas D. Fox, Zonghou Shen

      Pages 157-166

   2. Translation in Yeast Mitochondria

      • L. A. Grivell, P. J. T. Dekker, H. J. Pel

      Pages 167-176

   3. Yeast Mitochondrial Translation: Nuclear Genes Involved in the Expression of the Mitochondrial Genome

      • T. Rinaldi, M. Valens, M. Bolotin-Fukuhara

      Pages 177-191

7. Mitochondrial Import and Sorting

   1. Early Events in Protein Import into Mitochondria

      • K. Kassenbrock, M. Douglas, D. Cyr

      Pages 193-202

   2. Targeting Pathways to the Mitochondrial Inner Membrane

      • M. G. Cumsky, B. R. Miller, A. S. Gaikwad, L. A. Jung

      Pages 203-212

Due to fundamental similarities between the yeast Saccharomyces cerevisiae and multicellular organisms at the molecular level, and the powerful range of experimental tools available for this yeast, S. cerevisiae is proving an ideal model system for studies on protein synthesis and targeting. The topics covered are: - Messenger RNA stability and translation.- The translation apparatus. - Translational control andfidelity. - Protein targeting to the mitochondrion. - Nuclear transport. - The secretory pathway. - Protein folding and degradation. - Protein splicing. Modern and often novel molecular, genetic and biochemical approaches as well as most recent data are provided. The reader will gain a comprehensive view of the current status of the field.

• ATP
• Nucleotide
• RNA
• amino acid
• gene expression
• genome
• mitochondria
• mutation
• protein
• protein folding
• protein synthesis
• proteins
• synthesis
• translation
• yeast

• Department of Molecular & Cell Biology, University of Aberdeen, Marischal College, Aberdeen, UK

  Alistair J. P. Brown

• Biological Laboratory, The University, Canterbury, Kent, UK

  Mick F. Tuite

• Department of Gene Expression, GBF, Braunschweig, Germany

  John E. G. McCarthy

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