Overview
- Up-to-day findings on influence of miRNAs on gene translation
- Gives an overview on different microRNA types and functions in plants and animals
- Shows novel applications of microRNAs
- Includes supplementary material: sn.pub/extras
Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 50)
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Table of contents (7 chapters)
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Front Matter
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Back Matter
Keywords
About this book
The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).
Editors and Affiliations
Bibliographic Information
Book Title: miRNA Regulation of the Translational Machinery
Editors: Robert E. Rhoads
Series Title: Progress in Molecular and Subcellular Biology
DOI: https://doi.org/10.1007/978-3-642-03103-8
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2010
Hardcover ISBN: 978-3-642-03102-1Published: 18 November 2009
Softcover ISBN: 978-3-642-26140-4Published: 14 March 2012
eBook ISBN: 978-3-642-03103-8Published: 20 October 2009
Series ISSN: 0079-6484
Series E-ISSN: 2197-8484
Edition Number: 1
Number of Pages: X, 115
Number of Illustrations: 19 b/w illustrations, 4 illustrations in colour
Topics: Biochemistry, general, Cell Biology, Gene Expression, Molecular Medicine