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Post-Translational Modifications in Health and Disease

  • Book
  • © 2011

Overview

Editors:
  1. Cecilio J. Vidal

    1. Depto. Quimica Inorganica, Universidad Murcia, Murcia, Spain

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  • Over 40 color figures
  • Contains 19 updated reviews that stimulate further investigations in the proteomic field
  • Improves current understanding of protein modifications, allowing new avenues to prevent and/or alleviate human and animal diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Protein Reviews (PRON, volume 13)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Isoprenoid Modifications

    • Uyen T. T. Nguyen, Andrew Goodall, Kirill Alexandrov, Daniel Abankwa
    Pages 1-37

  3. GPI-Anchored Proteins in Health and Disease

    • David R. Taylor, Nigel M. Hooper
    Pages 39-55

  4. Protein Oxidation

    • C. Quiney, S. Finnegan, G. Groeger, T. G. Cotter
    Pages 57-78

  5. Involvement of S-Nitrosylation in Neurodegeneration

    • Yihang Li, Kenny K. K. Chung
    Pages 79-95

  6. Protein Glysosylation and Congenital Disorders of Glycosylation

    • Eva Morava, Dirk J. Lefeber, Ron A. Wevers
    Pages 97-117

  7. Defective Glycosylation of Dystroglycan in Muscular Dystrophy and Cancer

    • Federica Montanaro, Paul T. Martin
    Pages 119-143

  8. Protein Kinase A: The Enzyme and Cyclic AMP Signaling

    • Maria Nesterova, Constantine A. Stratakis
    Pages 145-169

  9. The Protein Kinase C Family: Key Regulators Bridging Signaling Pathways in Skin and Tumor Epithelia

    • Dirk Breitkreutz, Liora Braiman-Wiksman, Nicole Daum, Tamar Tennenbaum
    Pages 171-198

  10. Maintaining Energy Balance in Health and Disease: Role of the AMP-Activated Protein Kinase

    • John W. Scott
    Pages 199-232

  11. Protein Phosphatases in the Brain: Regulation, Function and Disease

    • Ry Y. Tweedie-Cullen, C. Sehwan Park, Isabelle M. Mansuy
    Pages 233-257

  12. Covalent Protein Modification as a Mechanism for Dynamic Recruitment of Specific Interactors

    • Nicholas R. Bertos, Veena Sangwan, Xiang-Jiao Yang, Morag Park
    Pages 259-279

  13. Regulation of Gene Expression by the Ubiquitin–Proteasome System and Implications for Neurological Disease

    • Lisa Lukaesko, Robert Meller
    Pages 281-315

  14. Small Ubiquitin-Like Modifiers and Other Ubiquitin-Like Proteins

    • Martijn van Hagen, Alfred C. O. Vertegaal
    Pages 317-340

  15. ER-associated Degradation and Its Involvement in Human Disease: Insights from Yeast

    • Nathalie Campagnolo, Michel Ghislain
    Pages 341-364

  16. Regulation of Chromatin Structure and Transcription Via Histone Modifications

    • Kajan Ratnakumar, Avnish Kapoor, Emily Bernstein
    Pages 365-385

  17. Chromatin: The Entry to and Exit from DNA Repair

    • Anastas Gospodinov, Zdenko Herceg
    Pages 387-409

  18. Poly(ADP-Ribosyl)ation of Chromosomal Proteins, Epigenetic Regulation and Human Genomic Integrity in Health and Disease

    • Rafael Alvarez-Gonzalez
    Pages 411-424

  19. Post-translational Proteolytic Processing on Intracellular Proteins by Cathepsins and Cystatins

    • Nobuhiko Katunuma, Masae Takahashi, Tadashi Tezuka
    Pages 425-456

  20. Metalloproteases and Proteolytic Processing

    • Anthony J. Turner, Natalia N. Nalivaeva
    Pages 457-482
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About this book

Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.

Editors and Affiliations

  • Depto. Quimica Inorganica, Universidad Murcia, Murcia, Spain

    Cecilio J. Vidal

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