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Mechanisms of Lymphocyte Activation and Immune Regulation VIII

Autoimmunity 2000 and Beyond

  • Book
  • © 2001

Overview

Editors:
  1. Sudhir Gupta

    1. University of California, Irvine, Irvine, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 490)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Basic Mechanisms

    1. Delineation of the Pathogenesis of Systemic Lupus Erythematosus by Using Murine Models

      • Kui Liu, Edward K. Wakeland
      Pages 1-6

    2. Factors Contributing to Autoimmune Disease

      • Kristine M. Garza, Linh T. Nguyen, Russell G. Jones, Pamela S. Ohashi
      Pages 7-19

    3. Control of Autoimmunity by Regulatory T Cells

      • Ethan M. Shevach, Rebecca S. McHugh, Angela M. Thornton, Ciriaco Piccirillo, Kannan Natarajan, David H. Margulies
      Pages 21-32

    4. Autoimmunity, Self-Tolerance and Immune Homeostasis: From Whole Animal Phenotypes to Molecular Pathways

      • Christopher C. Goodnow, Richard Glynne, Srini Akkaraju, Jane Rayner, David Mack, James I. Healy et al.
      Pages 33-40

    5. Peripheral Tolerance and Organ Specific Autoimmunity

      • Harald von Boehmer, Elmar Jaeckel
      Pages 41-48

    6. Autoimmune Lymphoproliferative Syndrome: Types I, II and Beyond

      • Hyung J. Chun, Michael J. Lenardo
      Pages 49-57

  4. Therapy

    1. Multiple Sclerosis and Gene Expression Profiling

      • Lawrence Steinman
      Pages 109-112

    2. Treatment of Autoimmunity by Inhibition of T Cell Costimulation

      • David I. Daikh, David Wofsy
      Pages 113-117

    3. Cytokine Blockade in Rheumatoid Arthritis

      • Marc Feldmann, Ravinder N. Maini, Jan Bondeson, Peter Taylor, Brian M. J. Foxwell, Fionula M. Brennan
      Pages 119-127

  5. Back Matter

    Pages 129-136
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Keywords

About this book

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies.
This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.

Editors and Affiliations

  • University of California, Irvine, Irvine, USA

    Sudhir Gupta

Bibliographic Information

  • Book Title: Mechanisms of Lymphocyte Activation and Immune Regulation VIII

  • Book Subtitle: Autoimmunity 2000 and Beyond

  • Editors: Sudhir Gupta

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1243-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2001

  • Hardcover ISBN: 978-0-306-46570-3Published: 31 July 2001

  • Softcover ISBN: 978-1-4613-5458-1Published: 25 September 2012

  • eBook ISBN: 978-1-4615-1243-1Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 136

  • Topics: Biochemistry, general, Immunology, Pathology, Microbiology

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