Animal Cell Technology: Basic & Applied Aspects

1. Front Matter

   Pages i-xv

   PDF

2. Process Validation for Virus Removal/Inactivation in the Bio-drug Purification Process

   1. Evaluation of Viral Safety of Biotechnology Products Derived from Cell Lines of Human or Animal Origin

      • Takao Hayakawa

      Pages 1-8

   2. Combination of Virus Removal and Inactivation for Optimization of Recovery of Protein

      • T. Tsuboi, N. Yamamoto

      Pages 9-15

   3. Strategy of Virus Removal / Inactivation of Plasma-Derived Products : Interest of Nanofiltration as a New Virus Elimination Method

      • T. Burnouf, M. Burnouf-Radosevich

      Pages 17-27

3. Insect Cell Culture and Baculovirus Expression

   1. Expression of the extracellular domain of the human growth hormone receptor gene by an insect-baculovirus system

      • Yoshimi Ota, Akira Asakura, Mayumi Minami

      Pages 29-34

   2. Expression of Recombinant Receptors in Insect Cells

      • B. C. Rooney, C. Woodcock, M. Pech, P. G. Strange

      Pages 35-40

   3. Production of a Transmission Blocking Vaccine Candidate of Rodent Malaria Plasmodium Berghei Using a Baculovirus Expression Vector System

      • J. Kobayashi, H. Matsuoka, Y. Chinzei, R. E. Sinden, S. Miyajima

      Pages 41-45

4. Human Monoclonal Antibodies; Production, Characterization and Clinical Experience

   1. Establishment of Human B Cell Lines Producing Antigen-specific Antibodies through SCID Mice Reconstituted with Human Peripheral Blood Lymphocytes

      • Naoto Uchibayashi, Akio Shino, Takahiro Ochi, Motofumi Okada, Yasuhito Okubo, Osamu Shiho

      Pages 47-51

   2. Production of Humanised Monoclonal Antibodies for In Vivo Imaging and Therapy

      • W. J. Harris

      Pages 53-61

   3. Clinical Results with Humanized and Human Monoclonal Antibodies

      • James B. Cornett

      Pages 63-73

   4. Clinical Applications of Human Monoclonal Antibodies

      • S. Hashizume, S. Sato, M. Kato, M. Kamei, K. Mochizuki, K. Kuroda et al.

      Pages 75-79

5. Transgenic Animals for Production of the Therapeutic Products

   1. Autocrine regulation of milk protein secretion

      • C. J. Wilde, C. V. P. Addey, A. J. Clark, S. E. Handel, M. A. Kerr, M. McClenaghan et al.

      Pages 81-86

   2. Therapeutic Applications of Transgenic Animals

      • Ramesh Kumar

      Pages 87-93

   3. FDA Perspective on the Use of Transgenic Animals in the Manufacture of Therapeutic Products Intended for Human Use: Safety Concerns

      • Joy A. Cavagnaro, Steven R. Bauer

      Pages 95-98

6. Cell Culture Technology in Tissue and Organ Engineering

   1. Hepatocyte Spheroid: Differentiated Features and Potential Utilization for the Bioreactor of Artificial Liver Support

      • N. Koide, H. Hada, T. Yada, K. Kimata, T. Ogura, T. Matsushita et al.

      Pages 99-101

   2. Microencapsulated Islets as a Bioartificial Pancreas

      • Tatsuya Takagi, Hiroo Iwata, Kazuo Kobayashi, Takayuki Oka, Hua Yang, Hiroshi Amemiya et al.

      Pages 103-114

   3. A Novel Three-Dimensional Long-Term Bone Marrow Bioreactor Culture System

      • Tzuu-Yi Wang, Athanassios Mantalaris, J. H. David Wu

      Pages 115-120

   4. Process Technology in Cellular and Tissue Engineering

      • B. A. Pierson, S. H. Chao, M. V. Peshwa, W. S. Hu

      Pages 121-126

7. Fish Cell Biotechnology

   1. Fish IGF-I and IGF-II: Age-Related and Tissue- Specific Expression and Transgenesis

      • Thomas T. Chen, Mike Shamblott, Jenn-Kan Lu

      Pages 127-135

   2. Inhibition of Aquatic Birnavirus Replication Process in Fish Cells by Viral Antisense RNA

      • Jen-Leih Wu, Shu-Chen Long, Sheau-Wen Yih, Chi-Yao Chang, Ching-Fong Liao, Ya-Li Hsu

      Pages 137-144

Animal cell technology is a growing discipline of cell biology which aims to understand the structure, function and behaviour of differentiated animal cells, and especially the development of such abilities as are useful for industrial purposes. These developments range from clonal expansion of differentiated cells with useful abilities, to optimization of cell culture on industrial scale and modulation of the cells' abilities to produce drugs and monoclonal antibodies.
The sixth volume in this series gives a complete review of today's state of the art in Japan, a country where this field is especially well advanced. It will be of interest to cell biologists, biochemists, molecular biologists, immunologists and other disciplines related to animal cell culture, working in the academic environment as well as in (biotechnology or pharmaceutical) industry.

• Expression
• biotechnology
• cell biology
• development
• protein
• tissue
• transgen
• transgenic animals

Policies and ethics