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Life Sciences - Animal Sciences | Molecular and Cell Biology of Neuropsychiatric Diseases

Molecular and Cell Biology of Neuropsychiatric Diseases

Owen, F., Itzhaki, Ruth (Eds.)

Softcover reprint of the original 1st ed. 1994, X, 201 p.

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  • About this book

is''0l m 5-HT Ante-mortem (m = metabolite) . ". ~ Post-mortem m 0 Noradrenaline ,,-'-'-'-'0-J ,,-'-'-'-'-'-'- m Dopamine ~ . '-'-'-'-'- . " Somatostatin . '1 Plaques Tangles * . ". . ". . 'I Synapse loss * ChAT " ACh synthesis l"-,. '-'-'-'-'-'-'-'-'-'-'-'-'- ,,-'-'-'-'-'-'-'-'-'-'-'-'-'-'- * Neuronal loss ,,- ,,- . ". * o 0. 1 0. 2 0. 3 0. 4 0. 5 0. 6 0. 7 0. 8 0. 9 1. 0 Correlation coefficient with dementia rating Figure 2. 1 Various neurotransmitter and neuropathological measures on neocortex obtained either at diagnostic craniotomy (ante-mortem) or post-mortem and re­ lationship to cognitive impairment (dementia rating). Asterisks identify significant correlations. Negative and positive correlations are not identified in this represen­ tation of the data. Only the physiologically relevant measure of cholinergic neurones (acetylcholine synthesis) and indices of cortical pyramidal neurone degeneration (neuronal loss, synapse loss and tangles) correlate with severity of dementia. Note the lack of correlation with the structural marker of cholinergic neurones, ChAT activity. Loss of enzyme exceeded that of acetylcholine synthesis (Sims et al. , 1983a), suggesting a compensatory increase in synthesis in the few remaining neurones. Data derived from Palmer (1987) and Terry et al. (1991). emission tomography (PET) and magnetic resonance, may some day pro­ vide routine insight into differences in brain functioning. Success in developing rapid and reliable diagnostic procedures, perhaps based on changes in body fluid that reflect specific alterations in brain protein metabolism, should ultimately play an important role in the clinical development of new therapeutic agents.

Content Level » Research

Keywords » Alzheimer - alzheimer's disease - biology - cell - cell biology - chemistry - dementia - depression - genetics - molecular biology - molecular genetics - neurochemistry - schizophrenia

Related subjects » Animal Sciences - Neurology - Neuroscience

Table of contents 

Molecular biology of Huntington's disease. Neuronal pathology in relation to molecular biology and treatment of Alzheimer's disease. The aetiology of Alzheimer's disease. The molecular genetics of Alzheimer's disease. The molecular biology of the transmissible dementias. The neurochemistry of schizophrenia. Molecular biology of shcizophrenia. Genetics and molecular biology of manic-depression. Index.

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