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Untranslated Gene Regions and Other Non-coding Elements

Regulation of Eukaryotic Gene Expression

  • Book
  • © 2013

Overview

Authors:
  1. Lucy W. Barrett

    1. (M518), CNND, The University of Western Australia, Crawley, Australia

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  2. Sue Fletcher

    1. , Centre Neuromuscular Disorders (CNND), The University of Western Australia, Crawley, Australia

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    You can also search for this author in PubMed   Google Scholar

  3. Steve D. Wilton

    1. , CNND, The University of Western Australia, Crawley, Australia

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    You can also search for this author in PubMed   Google Scholar

  • Revisits the idea of "junk" genetic material
  • Easy to read, concise overview of a complex subject
  • Includes supplementary material: sn.pub/extras

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology (BRIEFSBIOCHEM)

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Table of contents (1 chapter)

  1. Front Matter

    Pages i-viii
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  2. Untranslated Gene Regions and Other Non-coding Elements

    • Lucy W. Barrett, Sue Fletcher, Steve D. Wilton
    Pages 1-56
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Keywords

About this book

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

Authors and Affiliations

  • (M518), CNND, The University of Western Australia, Crawley, Australia

    Lucy W. Barrett

  • , Centre Neuromuscular Disorders (CNND), The University of Western Australia, Crawley, Australia

    Sue Fletcher

  • , CNND, The University of Western Australia, Crawley, Australia

    Steve D. Wilton

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